Abstract: Treatment of male infertility started from the intrauterine insemination with husband's semen
（IUH）. In the early stage, assisted reproductive technology（ART）was mainly for female patients with infertility，specifically for the tubal factor infertility. The outcome of ART treatment of male factor infertility was not goodas that of female factor infertility, because of the low in vitro fertilization rate due to the low spermatozoamotility. To get clinical pregnancies, Gordon and Talansly in 1988 successfully developed 忆zona drilling （ZD）忆，and Cohen developed 'partial zonal dissection（PZD）'. Although these techniques partially overcome the diffic-ulties of fertilization, they were not widely applied due to the low monospermic fertilization rate （15%-25%），the high polyspermic fertilization rate，the relative high requirement for sperm number and motility，and the low clinical pregnancy rate （10%）. In 1992, Palermo successfully developed the intracytoplasmic sperm injection
（ICSI）technique for the creative treatment of male infertility. ART should never be the first choice for thetreatment of male infertility，it isa important backup choice after routine treatment. The good treatment for maleinfertility should be evaluated overall factors，including male fertility function, fertility ability of female partner，selectable ART methods，safety and low-invasiveness and low cost.

Key words: Infertility, male, Reproductive techniques, assisted, Fertilization in Vitro, Embryo transfer, Sperm injections, intracytoplasmic