Abstract: Bisphenol A（BPA） is widely used for the manufacturing of polycarbonate plastic and expoxide resins in the modern industrial world. Meanwhile，it has potential estrogenic properties. Due to its broad and sufficient usage in the daily life，mammal including humans is widely exposed to BPA, which is a potential risk of health lesion. The results from laboratory experiments showed that the offspring or newborn animals would have some kinds of diseases such as precocious puberty，the abnormality in breast tissue development，prostatic hyperplasia and decline in spermatogenesis if the pregnant animals or newborns were exposed to BPA, which finally lead to premalignant lesions of breast tissue and severe lesions of genital tract. Besides，the clinical investigation also showed that BPA had some obvious adverse effects on human reproductive system, such as male sexual dysfunctions.

Key words: Mammals, Male urogenital diseases, Female urogenital diseases, Bisphenol A