Abstract: On the happy occasion of the 25th anniversary of successful application of ART in mainland of China，it is advisable to review ART development history in China，to investigate challenges and opportunities，and to develop an overall plan for the future.
One Standpoint: ART is a significant milestone in Biomedicine History.
Two Reflections: ART is not necessary the best approach and /or the first choice for infertility management;
ART needs strict and systematic safety review and evaluation.
Three Challenges: How to improve successful rate of ART?
How to reduce the potential risks of ART?
How to develop an enabling bioethical environment for ART?
Four Recommendations: Interdisciplinary Research on ART and its Safety;
National ART Network and Database;Capacity Building of ART Staffs;
International Communication and Collaboration.

Key words: Reproductive techniques, assisted, Successful rate, Potential risks, Bioethical principles