Abstract: The modern endocrine system has been conceptually expanded to almost all tissues or cells of human body. Activation of the pulsatile secretion of hypothalamic GnRH-Pituitary Gn is the key step of initiating ovarian function, which is related to other four hypothalamic endocrine systems. Both the neuroendocrine-immune network and neuroendocrine-nutrition regulating network also impact the GnRH-Gn pulsatile secretion or ovarian gametogenesis, as well as steroidogenesis. This paper discussed the influence of systemic endocrine diseases on female reproduction，and elucidated the effects of stress on the systemic endocrine organs and ovarian axis by a psychoneuroendocrine disorder, functional hypothalamic anovulaton.

Key words: Thyroxine, Prolactin, Glucocorticoids, Growth hormone, Insulin