Abstract: Recent studies found that Pten, a tumor suppressor gene, and PTEN protein played an important role in regulating cell growth， differentiation and apoptosis through the PI3K pathway. In the female reproductive system, PTEN plays an important role in regulating follicular development, reproductive aging and years by controlling the survival and activation of primordial follicles， the proliferation and differentiation of granulosa cells though the PTEN-PI3K-PDK1 signaling networks. By the same networks, PTEN regulates the endometrial proliferation, and the implantation and development of early embryo.

Key words: PTEN phosphohydrolase, Genes, Female urogenital diseases, Ovarian follicle, Endometrium, Embryonic development