Abstract: Objective：To evaluate the application of the combined multiple parameters in the early diagnosis of ectopic pregnancy，including serum β-hCG and progesterone，and endometrial thickness （EST）. Methods：127 cases in our hospital from July 2008 to May 2010 were confirmed by B-Ultrasound and pathological exam after the positive test of urine hCG. Those cases were divided into three groups，the ectopic pregnancy group （48 cases），the normal pregnancy group （40 cases），and the pregnancy abortion group （39 cases）. The β-hCG and progesterone levels were analyzed by electrochemiluminescence （ECL）. EST was measured by B-Ultrasound. The significances of those parameters were compared by the area under curve （AUC） of ROC curve. Results：The increased β-hCG value （the ratio of 48 h/0 h） in the ectopic pregnancy group was smaller，when compared with those in the normal pregnancy group and the pregnancy abortion group （P＜0.05）. Progesterone level in the ectopic pregnancy group，as well as EST value，was significantly lower than those in other groups （P＜0.05）. The ROC curves showed that three combined parameters had the highest diagnostic accuracy （AUC=0.915）. Three parameters had different accuracy to detect respectively the early ectopic pregnancy as follows：β-hCG （the ratio of 48 h/0 h，AUC=0.875），progesterone （AUC=0.806），EST （AUC=0.782）. Conclusions：Serum β-hCG （the ratio of 48 h/0 h），progesterone and EST had limited significances to detect respectively the early ectopic pregnancy. Three combined parameters had the highest diagnosis accuracy，which should be recommended.

Key words: Pregnancy, ectopic, Chorionic gonadotropin, beta subunit, human, Progesterone, Endometrium, ROC curve