Abstract: Cervical cancer is a common gynecologic malignant tumor with the increasing morbidity and the transition of young age. Radiotherapy is an important treatment of cervical cancer. For those patients withⅠa1 to Ⅱa2 stage cervical cancer, radical surgery alone has the similar effect with the radical chemoradiotherapy. For those patients with Ⅱb to Ⅳa stage cervical cancer, the concurrent chemoradiotherapy is the main treatment. With the development of radiotherapy equipment, the radiotherapy curative effect has been well improved. However, there are some patients being not sensitive to radiation with poor prognosis. Changes of multiple genes and moleculars were found to be associated with the radiosensitivity of cervical cancer. RNA interference（ＲＮＡｉ） has been studied to increase the radiosensitivity of many cancer as a potential clinical application. In this paper, RNAi of several particular genes, so as to increase the radiosensitivity of cervical cancer, are reviewed.

Key words: RNA interference, Uterine cervical neoplasms, Gene silencing, Radiosensitivity