Abstract: The long protocol of GnRH agonist for the ovulation induction in infertility treatment has been accepted by assisted reproductive technology (ART). However, in recent years, the GnRH antagonist has also been widely used in clinical practice due to its short-time, safety, no "flare-up" and reserved response. The GnRH antagonist protocol can significantly lower the occurrence of ovarian hyperstimulation syndrome (OHSS), while it has little undesirable influence in those patients with the normal response. The application of GnRH antagonist has also been tried in those patients with the low response. How to personalize the protocol of GnRH antagonist has been the research hotpot in ART area. We introduced the personalized protocols of GnRH antagonist for those patients with different responses and the other protocols derived from GnRH antagonist.

Key words: Fertilization in vitro, Embryo transfer, Gonadotropin-releasing hormone antagonist, Ovary, Pregnancy outcome