Abstract: Premature ovarian failure（ＰＯＦ） is diagnosed by amenorrhea, along with the elevated follicle stimulating hormone（ＦＳＨ） and the decreased estrogen （Ｅ２） levels in women before 40 years old. POF has a severe impact on the endocrine function, fertility and mental state of those women. In recent years, the proportion of patients with POF in female infertility has a rising trend. The amenorrhea and low-estrogen level caused by POF can be improved by hormone replacement therapy （ＨＲＴ）, while the treatment for infertility need more exploratory study and clinical practice, including ovulation induction, oocyte donation transplant, egg cryopreservation technology, as well as some new technologies such as gene therapy, stem cells therapy and in-vitro activation（ＩＶＡ）. The gene therapy and the stem cells therapy have been made some progress in animal tests. These achievements bring POF patients a new hope in the recovery of fertility. IVA is a further exploration to activate the residual dormant follicles for those POF infertility women, although the success rate is not satisfactory. However, there have been some successful cases of IVA treatment. In this paper, the progress in the treatment of infertility related to POF was discussed.

Key words: Ovarian failure, premature, Infertility, female, Gene therapy, Stem cells, In-vitro activation