Abstract: Objective：To investigate the effects of female hepatitis B virus (HBV) infection on outcomes after frozen-thawed embryo transfer (FET). Methods: The baseline characteristics and data of FET cycles in both the HBV group (couples with an HBsAg-positive female partner and an HBsAg-negative male partner) and the control group (couples with both HBsAg-negative partner) were retrospectively analyzed. Multivariate logistic regression was used to test for the association between clinical pregnancy and maternal HBV infection. P＜0.05 was considered statistically significant. Results: A total of 93 FET cycles were included in this study, including 31 cycles in the HBV group and 62 cycles in the control group. There were no significant differences in those baseline characteristics between the two groups (P＞0.05). The HBV group had mildly higher clinical pregnancy rate (45.2% vs. 40.3%, P=0.656) and embryo implantation rate (31.3% vs. 25.0%, P=0.361) when compared with the control group. Multivariate logistic regression analysis showed that maternal HBV infection was not associated with clinical pregnancy in FET cycles (OR=1.219, 95%CI=0.510-2.911, P=0.656). Conclusions: Maternal HBV infection had not adverse effect on clinical pregnancy rate after FET.

Key words: Hepatitis B virus, Frozen-thawed embryo transfer, Clinical pregnancy