Abstract: With the development of RNA sequencing, cyclic RNA (circRNA) has been a research hot which is a member of the newly discovered RNA family. CircRNA is a kind of RNA with a special closed ring structure. Because of the special morphology, circRNA has some characteristics which are different from those of linear RNA. CircRNA is stable and conservative across species, and has tissue and cell specificity. CircRNA can act as the so-called microRNA (miRNA) sponge in the circRNA-miRNA-mRNA regulatory axis, regulating gene transcription and protein translation. Studies have found that the pathogenesis of female reproductive diseases may be closely related to the abnormality of circRNA. By studying the characteristics and mechanisms of various circRNA, circRNA may be used as a biomarker and prognostic indicator of disease in future. The article reviews the potential mechanisms of circRNA in female reproductive system and diseases.

Key words: Circular RNA, MicroRNAs, Genital neoplasms, female, Reproductive techniques, assisted, Review