CircRNA and Pregnancy-Related Diseases

doi:10.12280/gjszjk.20220227

Abstract

Abstract:

Circular RNA (circRNA) is composed of the non-coding RNAs generated by a noncanonical splicing event which called reverse splicing. In reverse splicing, the downstream splicing site is covalently connected to the upstream splicing receptor site. CircRNA with stable structure widely exists in various eukaryotic cells and organisms. With the rapid development of molecular biotechnology such as high-throughput sequencing, the biological role of circRNA has been revealed. CircRNA has become a star in the field of biological research. Studies in recent years have found the different expression of circRNA in the placental tissue and maternal plasma of pathological pregnancy. CircRNA influences the occurrence and development of pregnancy diseases by participating in the regulation of trophoblast epithelial stromal transformation, placental microvasculogenesis, glucose and lipid metabolism homeostasis during pregnancy, and by mediating the microenvironment of maternal and fetal interface inflammation. CircRNA also interacts with miRNA and RNA-binding proteins, in which regulates placental autophagy and maternal fat metabolism. This paper aims to introduce circRNA and its research progress in pregnancy-related diseases.

Key words: Circular RNA, Abortion, habitual, Pre-eclampsia, Diabetes, gestational, Hypertension, pregnancy-induced

GAO Qian-qian, FENG Xiao-ling. CircRNA and Pregnancy-Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 430-435.

References 35

[1]	Kristensen LS, Andersen MS, Stagsted L, et al. The biogenesis, biology and characterization of circular RNAs[J]. Nat Rev Genet, 2019, 20(11):675-691. doi: 10.1038/s41576-019-0158-7. doi: 10.1038/s41576-019-0158-7 pmid: 31395983
[2]	Hanan M, Soreq H, Kadener S. CircRNAs in the brain[J]. RNA Biol, 2017, 14(8):1028-1034. doi: 10.1080/15476286.2016.1255398. doi: 10.1080/15476286.2016.1255398 pmid: 27892769
[3]	Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures[J]. Proc Natl Acad Sci U S A, 1976, 73(11):3852-3856. doi: 10.1073/pnas.73.11.3852. doi: 10.1073/pnas.73.11.3852 pmid: 1069269
[4]	柯双熬, 赵胜男, 刘玉, 等. 环状RNA翻译蛋白在癌症中的研究进展[J]. 生物工程学报,2022 Apr 12. doi: 10.13345/j.cjb.210909.[Epub ahead of print]. doi: 10.13345/j.cjb.210909
[5]	Zhang YP, Ye SZ, Li YX, et al. Research Advances in the Roles of Circular RNAs in Pathophysiology and Early Diagnosis of Gestational Diabetes Mellitus[J]. Front Cell Dev Biol, 2021, 9:739511. doi: 10.3389/fcell.2021.739511. doi: 10.3389/fcell.2021.739511 URL
[6]	谢来娣, 刘爱霞. 环状RNA在滋养细胞功能障碍相关疾病中的研究进展[J]. 中华生殖与避孕杂志, 2021, 41(9):850-856. doi: 10.3760/cma.j.cn101441-20200413-00211. doi: 10.3760/cma.j.cn101441-20200413-00211
[7]	Wu YL, Li HF, Chen HH, et al. Emergent Roles of Circular RNAs in Metabolism and Metabolic Disorders[J]. Int J Mol Sci, 2022, 23(3):1032. doi: 10.3390/ijms23031032. doi: 10.3390/ijms23031032 URL
[8]	Dai W, Liu X. Circular RNA 0004904 promotes autophagy and regulates the fused in sarcoma/vascular endothelial growth factor axis in preeclampsia[J]. Int J Mol Med, 2021, 47(6):111. doi: 10.3892/ijmm.2021.4944. doi: 10.3892/ijmm.2021.4944 URL
[9]	Li H, Deng Z, Yang H, et al. circRNA-binding protein site prediction based on multi-view deep learning, subspace learning and multi-view classifier[J]. Brief Bioinform, 2022, 23(1):bbab394. doi: 10.1093/bib/bbab394. doi: 10.1093/bib/bbab394 URL
[10]	Okholm T, Sathe S, Park SS, et al. Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression[J]. Genome Med, 2020, 12(1):112. doi: 10.1186/s13073-020-00812-8. doi: 10.1186/s13073-020-00812-8 pmid: 33287884
[11]	Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine[J]. Cell Res, 2017, 27(5):626-641. doi: 10.1038/cr.2017.31. doi: 10.1038/cr.2017.31 pmid: 28281539
[12]	Chen N, Zhao G, Yan X, et al. A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1[J]. Genome Biol, 2018, 19(1):218. doi: 10.1186/s13059-018-1594-y. doi: 10.1186/s13059-018-1594-y
[13]	Cao M, Wen J, Bu C, et al. Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients[J]. BMC Pregnancy Childbirth, 2021, 21(1):303. doi: 10.1186/s12884-021-03777-7. doi: 10.1186/s12884-021-03777-7 URL
[14]	Jiang M, Lash GE, Zhao X, et al. CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia[J]. Cell Physiol Biochem, 2018, 46(6):2576-2586. doi: 10.1159/000489685. doi: 10.1159/000489685 pmid: 29758559
[15]	Zhang Y, Cao L, Jia J, et al. CircHIPK3 is decreased in preeclampsia and affects migration, invasion, proliferation, and tube formation of human trophoblast cells[J]. Placenta, 2019, 85:1-8. doi: 10.1016/j.placenta.2019.07.010. doi: S0143-4004(19)30520-X pmid: 31421528
[16]	Shan L, Hou X. Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR-331-3p/TGF-βR1 axis in pre-eclampsia[J]. Mol Med Rep, 2021, 24(5):798. doi: 10.3892/mmr.2021.12438. doi: 10.3892/mmr.2021.12438 URL
[17]	Li Z, Zhou X, Gao W, et al. Circular RNA VRK1 facilitates pre-eclampsia progression via sponging miR-221-3P to regulate PTEN/Akt[J]. J Cell Mol Med, 2022, 26(6):1826-1841. doi: 10.1111/jcmm.16454. doi: 10.1111/jcmm.16454 URL
[18]	Zhang Y, Yang H, Zhang Y, et al. CircSFXN1 regulates the behaviour of trophoblasts and likely mediates preeclampsia[J]. Placenta, 2020, 101:115-123. doi: 10.1016/j.placenta.2020.09.012. doi: S0143-4004(20)30304-0 pmid: 32950919
[19]	Zou H, Mao Q. Circ_0037078 promotes trophoblast cell proliferation, migration, invasion and angiogenesis by miR-576-5p/IL1RAP axis[J]. Am J Reprod Immunol, 2022, 87(1):e13507. doi: 10.1111/aji.13507. doi: 10.1111/aji.13507
[20]	Li C, Li Q. Circular RNA circ_0111277 Serves as ceRNA, Targeting the miR-424-5p/NFAT5 Axis to Regulate the Proliferation, Migration, and Invasion of Trophoblast Cells in Preeclampsia[J]. Reprod Sci, 2022, 29(3):923-935. doi: 10.1007/s43032-021-00715-y. doi: 10.1007/s43032-021-00715-y URL
[21]	Qian Y, Wang X, Ruan H, et al. Circular RNAs expressed in chorionic villi are probably involved in the occurrence of recurrent spontaneous abortion[J]. Biomed Pharmacother, 2017, 88:1154-1162. doi: 10.1016/j.biopha.2017.01.172. doi: 10.1016/j.biopha.2017.01.172 URL
[22]	Li C, Chen X, Liu X, et al. CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage[J]. Genes Dis, 2020, 7(3):414-423. doi: 10.1016/j.gendis.2019.06.003. doi: 10.1016/j.gendis.2019.06.003 pmid: 32884996
[23]	Zhu L, Shi L, Ye W, et al. Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis[J]. Bioengineered, 2021, 12(1):6878-6890. doi: 10.1080/21655979.2021.1973207. doi: 10.1080/21655979.2021.1973207 pmid: 34519628
[24]	Gao Y, Tang Y, Sun Q, et al. Circular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade[J]. Bioengineered, 2021, 12(1):9081-9093. doi: 10.1080/21655979.2021.1988374. doi: 10.1080/21655979.2021.1988374 pmid: 34654357
[25]	Li Z, Zhou G, Tao F, et al. circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression[J]. Biochem Biophys Res Commun, 2020, 531(4):472-479. doi: 10.1016/j.bbrc.2020.06.117. doi: 10.1016/j.bbrc.2020.06.117 URL
[26]	Tang M, Bai L, Wan Z, et al. circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion[J]. Mol Ther Nucleic Acids, 2021, 26:1433-1445. doi: 10.1016/j.omtn.2021.06.012. doi: 10.1016/j.omtn.2021.06.012 URL
[27]	Tang L, Li P, Li L. Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus[J]. J Diabetes Investig, 2020, 11(5):1307-1317. doi: 10.1111/jdi.13250. doi: 10.1111/jdi.13250 URL
[28]	Jiang B, Zhang J, Sun X, et al. Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM[J]. J Transl Med, 2022, 20(1):5. doi: 10.1186/s12967-021-03195-5. doi: 10.1186/s12967-021-03195-5 pmid: 34980149
[29]	张燕萍, 陈佳丽, 习阳, 等. 环状RNA在妊娠期糖尿病病理生理及诊断中的研究进展[J]. 生命的化学, 2021, 41(12):2606-2613. doi: 10.13488/j.smhx.20210371. doi: 10.13488/j.smhx.20210371
[30]	Zhang YP, Ye SZ, Li YX, et al. Research Advances in the Roles of Circular RNAs in Pathophysiology and Early Diagnosis of Gestational Diabetes Mellitus[J]. Front Cell Dev Biol, 2021, 9:739511. doi: 10.3389/fcell.2021.739511. doi: 10.3389/fcell.2021.739511 URL
[31]	Wang H, Zhou W, She G, et al. Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the β-catenin and NF-κB pathways[J]. Reprod Biol Endocrinol, 2020, 18(1):51. doi: 10.1186/s12958-020-00612-0. doi: 10.1186/s12958-020-00612-0 URL
[32]	张薇. Circ_0001578通过介导胎盘炎症反应促进妊娠期糖尿病发生发展的机制研究[D]. 沈阳: 中国医科大学, 2021.
[33]	Zhang L, Zeng M, Tang F, et al. Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis[J]. Diabetol Metab Syndr, 2021, 13(1):58. doi: 10.1186/s13098-021-00678-9. doi: 10.1186/s13098-021-00678-9
[34]	王健, 史云, 顾秀峰, 等. 环状RNA在妊娠期高血压患者中的表达及潜在作用机制[J]. 淮海医药, 2021, 39(5):461-465. doi: 10.14126/j.cnki.1008-7044.2021.05.006. doi: 10.14126/j.cnki.1008-7044.2021.05.006
[35]	阿燕·西合斯, 罗健, 邵明明, 等. 淋巴细胞连接蛋白调控JAK-STAT信号通路在高血压血管重构中的作用[J]. 国际心血管病杂志, 2021, 48(3):168-173. doi: 10.3969/j.issn.1673-6583.2021.03.011. doi: 10.3969/j.issn.1673-6583.2021.03.011