Abstract: Cervical cancer is the most common malignant tumor in the female reproductive system in the world, ranking the third in the incidence of female malignant tumor. Local advanced cervical cancer (LACC) is characterized by being easy to invade, high rate of lymphatic metastasis, difficulty of operation, and being easy to relapse. The curative effect is uncertain, and there is still no unified treatment program. The study found that neoadjuvant chemotherapy (NACT) could reduce tumor size, improve surgical resection rate and surgical effect, increase radiotherapy sensitivity, reduce recurrence rate and metastasis rate, and improve the prognosis of LACC. At the same time, it was found that NACT could control the disease, prolong the gestation period and improve the outcomes of mother and child for special patients who need to retain the reproductive function and the complicated pregnancy. Therefore, this article reviews the efficacy of NACT in LACC.

Key words: Uterine cervical neoplasms, Antineoplastic combined chemotherapy protocols, Chemoradiotherapy, Chemotherapy, adjuvant, Radiotherapy, Neoadjuvant chemotherapy