Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2020, Vol. 39 ›› Issue (6): 499-503.

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Immune-Related Factors of Recurrent Spontaneous Abortion

LI Qi-yan，WANG Yi-ying，WANG Tian-tian，WEI Li   

  1. Department of Obstetrics and Gynecology，Henan University People′s Hospital，Henan Provincial People′s Hospital，Zhengzhou 450003，China（LI Qi-yan，WANG Yi-ying，WEI Li）；Department of Obstetrics and Gynecology，Zhengzhou University Third Affiliated Hospital，Zhengzhou 450052，China（WANG Tian-tian）
  • Received:2020-04-29 Revised:2020-06-30 Published:2020-11-15 Online:2020-11-15
  • Contact: WEI Li，E-mail：weili196266@163.com E-mail:weili196266@163.com

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Abstract: Recurrent spontaneous abortion (RSA) generally refers to 3 or more consecutive miscarriages with same-sex couples before 20 weeks of gestation. The cause of RSA is still unknown, immune-related factor could be an important cause. Those factors of immune abnormality are not only related to the changes of maternal autoimmune, but also related to the imbalance of maternal-fetal immune tolerance. Further studies on RSA immune-related factors are of great significance for exploring new treatment methods of RSA and improving pregnancy outcomes in RSA patients. In this paper, the immune-related factors and progress of RSA are reviewed in order to provide new ideas for the diagnosis and treatment of RSA.

Key words: Abortion, habitual；, Autoimmunity；, Autoantibodies；, Maternal-fetal immune tolerance