N6-Methyladenosine in Reproductive System: Effect and Regulation

doi:10.12280/gjszjk.20200653

Abstract

Abstract:

N6-methyladenosine (m⁶A) is the most common RNA modification in eukaryotic cells. Under the dynamic regulation of methylase, demethylase and binding protein, m⁶A modification is involved in RNA metabolism processes, such as RNA splicing, nucleation and translation and so on. In recent years, many studies have shown that the RNA m⁶A modification plays an indispensable role in the reproductive processes, such as oocyte maturation and spermatogenesis. During oocyte maturation, the dynamic regulation network of m⁶A affects the assembly of chromosomes and spindles, interferes with meiosis and impedes the development of follicles. In granulosa cells, apoptosis of granulosa cells caused by the abnormal m⁶A is related to POI and PCOS. In the male reproductive system, the deficiency of m⁶A-related enzyme could damage the motility, number and morphology of sperm in mice, while the m⁶A level in semen was increased in patients with asthenospermia. The combination of new technologies such as artificial intelligence and m⁶A sequencing technology provides a new direction for the exploration of m⁶A dynamic network in the future.

Key words: N6-methyladenosine, RNA, Oocytes, Spermatozoa, Spermatogenesis

ZHANG Meng-hui, LIU Xiao-cong, GUO Yi-hong. N6-Methyladenosine in Reproductive System: Effect and Regulation[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(4): 306-309.

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