HIF-1α and Related Pathways in the Pathogenesis of Endometriosis

doi:10.12280/gjszjk.20220057

Abstract

Abstract:

The pelvic hypoxic microenvironment is an important factor of the pathogenesis and development of endometriosis (EMs), in which the induced expression of hypoxia-inducible factor-1α (HIF-1α) participates in the angiogenesis, inflammatory response, as well as the proliferation, apoptosis, migration, invasion and epithelial-mesenchymal transition (EMT) of endometrial cells. More and more studies showed that the HIF-1α/Wnt/β-catenin, HIF-1α/lncRNA UBOX5-AS1, HIF-1α/ LATS1/YAP1 and GPER/HIF-1α/MMP-9 pathway participated in the migration, invasion and EMT; HIF-1α/TGF-β1/Smad and HIF-1α/EZH2/ANTXR2 in the cell adhesion; PI3K/AKT/HIF-1α, HIF-1α/ DUSP2/IL-6/STAT3 and HIF-1α/miR-210 pathway in the cell survive and proliferation; HIF-1α/miR-20a, miR-199a/HIF-1α/VEGF and HIF-1α/COUP-TFⅡ/Ang pathway in the angiogenesis of ectopic endometrial tissue. The recent studies also showed the characteristics of aerobic glycolysis in ectopic endometrial tissue and the autophage activated by HIF-1α. In this review, we summarized the effects of HIF-1α and its related signaling pathways in the EMs for further exploring the pathogenesis of EMs.

Key words: Endometriosis, Hypoxia, Hypoxia-inducible factor 1,alpha subunit, Signal transduction, Cell proliferation, Apoptosis, Neovascularization,pathology

WEN Ping-hua, WANG Xi-wen, ZHANG Wei, LIU Yi, LIU Heng-wei. HIF-1α and Related Pathways in the Pathogenesis of Endometriosis[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(3): 258-264.

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