Research Progress of Brain-Derived Neurotrophic Factor and Female Reproduction

doi:10.12280/gjszjk.20220501

Abstract

Abstract:

Brain-derived neurotrophic factor (BDNF) is a member of the family of neurotrophic factors. When combined with its receptors, BDNF plays an important role in the development and differentiation of neurons. Recent studies have found that BDNF is also expressed in the female reproductive system and plays an important role in female reproductive endocrine. In the ovary, BDNF can promote follicle development, oocyte growth and maturation, ovulation and so on. In the utero, BDNF can regulate the endometrial receptivity by promoting endometrial proliferation, making it easier to adapt to embryo implantation, and promoting embryo and placenta development. The abnormal expression of BDNF is closely related to the occurrence of polycystic ovary syndrome, diminished ovarian reserve, endometriosis and other diseases. Therefore, it is of great significance to study the expression of BDNF in the reproductive system, its influence on reproductive function and the correlation with the reproduction-related diseases. In this paper, we summarize the reports on BDNF and female reproductive function and the related diseases, so as to provide a certain reference for improving female reproductive function and treating the related diseases.

Key words: Brain-derived neurotrophic factor, Ovarian follicle, Polycystic ovary syndrome, Ovarian reserve, Endometriosis

ZHU Wen-bin, XU Jing-yu, MA Rui-hong, XIA Tian, LUAN Zu-qian. Research Progress of Brain-Derived Neurotrophic Factor and Female Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(2): 140-144.

References 38

[1]	Qin X, Zhao Y, Zhang T, et al. TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice[J]. Nat Commun, 2022, 13(1):914. doi: 10.1038/s41467-022-28611-2. doi: 10.1038/s41467-022-28611-2 pmid: 35177657
[2]	Dong F, Zhang Q, Kong W, et al. Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway[J]. Gynecol Endocrinol, 2017, 33(6):485-489. doi: 10.1080/09513590.2017.1295439. doi: 10.1080/09513590.2017.1295439 pmid: 28277116
[3]	陈子江, 刘嘉茵, 黄荷凤, 等. 不孕症诊断指南[J]. 中华妇产科杂志, 2019, 54(8):505-511. doi: 10.3760/cma.j.issn.0529-567x.2019.08.001. doi: 10.3760/cma.j.issn.0529-567x.2019.08.001
[4]	Chow R, Wessels JM, Foster WG. Brain-derived neurotrophic factor (BDNF) expression and function in the mammalian reproductive Tract[J]. Hum Reprod Update, 2020, 26(4):545-564. doi: 10.1093/humupd/dmaa008. doi: 10.1093/humupd/dmaa008 pmid: 32378708
[5]	Xu HX, Lin SX, Gong Y, et al. Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model[J]. Front Pharmacol, 2020, 11:245. doi: 10.3389/fphar.2020.00245. doi: 10.3389/fphar.2020.00245 URL
[6]	Cao M, Niu Q, Xiang X, et al. Brain-Derived Neurotrophic Factor Regulates Ishikawa Cell Proliferation through the TrkB-ERK1/2 Signaling Pathway[J]. Biomolecules, 2020, 10(12):1645. doi: 10.3390/biom10121645. doi: 10.3390/biom10121645 URL
[7]	Seifer DB, Feng B, Shelden RM, et al. Brain-derived neurotrophic factor: a novel human ovarian follicular protein[J]. J Clin Endocrinol Metab, 2002, 87(2):655-659. doi: 10.1210/jcem.87.2.8213. doi: 10.1210/jcem.87.2.8213 URL
[8]	付娟, 陈士岭, 邢福祺, 等. 脑源性神经营养因子及其受体在人卵巢的表达与卵泡发育的关系[J]. 中国免疫学杂志, 2005, 21(1):40-44. doi: 10.3321/j.issn:1000-484X.2005.01.010. doi: 10.3321/j.issn:1000-484X.2005.01.010
[9]	Dissen GA, Hirshfield AN, Malamed S, et al. Expression of neurotrophins and their receptors in the mammalian ovary is developmentally regulated: changes at the time of folliculogenesis[J]. Endocrinology, 1995, 136(10):4681-4692. doi: 10.1210/endo.136.10.7664689. doi: 10.1210/endo.136.10.7664689 pmid: 7664689
[10]	Ojeda SR, Romero C, Tapia V, et al. Neurotrophic and cell-cell dependent control of early follicular development[J]. Mol Cell Endocrinol, 2000, 163(1/2):67-71. doi: 10.1016/s0303-7207(99)00242-7. doi: 10.1016/s0303-7207(99)00242-7 URL
[11]	Paredes A, Romero C, Dissen GA, et al. TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary[J]. Dev Biol, 2004, 267(2):430-449. doi: 10.1016/j.ydbio.2003.12.001. doi: 10.1016/j.ydbio.2003.12.001 pmid: 15013804
[12]	Wang X, Sun Z, Zhen J, et al. Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients[J]. J Assist Reprod Genet, 2011, 28(11):1053-1058. doi: 10.1007/s10815-011-9635-4. doi: 10.1007/s10815-011-9635-4 URL
[13]	李娜, 王朕华, 王悦, 等. 脑源性神经营养因子及其受体在小鼠卵母细胞第一极体释放中的作用[J]. 中国计划生育学杂志, 2021, 29(8):1559-1562,1778. doi: 10.3969/j.issn.1004-8189.2021.08.003. doi: 10.3969/j.issn.1004-8189.2021.08.003
[14]	Zhang Q, Liu D, Zhang M, et al. Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome[J]. Reprod Fertil Dev, 2016, 28(12):1904-1915. doi: 10.1071/RD15131. doi: 10.1071/RD15131 URL
[15]	Wu LM, Hu MH, Tong XH, et al. Chronic unpredictable stress decreases expression of brain-derived neurotrophic factor (BDNF) in mouse ovaries: relationship to oocytes developmental potential[J]. PLoS One, 2012, 7(12):e52331. doi: 10.1371/journal.pone.0052331. doi: 10.1371/journal.pone.0052331 URL
[16]	Chen S, Wang F, Liu Z, et al. Brain-derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells[J]. J Cell Physiol, 2019, 234(6):8776-8787. doi: 10.1002/jcp.27536. doi: 10.1002/jcp.27536 pmid: 30456817
[17]	Zhao X, Du F, Liu X, et al. Brain-derived neurotrophic factor (BDNF) is expressed in buffalo (Bubalus bubalis) ovarian follicles and promotes oocyte maturation and early embryonic development[J]. Theriogenology, 2019, 130:79-88. doi: 10.1016/j.theriogenology.2019.02.020. doi: S0093-691X(18)30948-8 pmid: 30877846
[18]	Kawamura K, Kawamura N, Mulders SM, et al. Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos[J]. Proc Natl Acad Sci U S A, 2005, 102(26):9206-9211. doi: 10.1073/pnas.0502442102. doi: 10.1073/pnas.0502442102 URL
[19]	陈璐. 脑源性神经营养因子及神经营养因子4对大鼠促性腺激素分泌及其受体表达的影响[D]. 长春: 吉林大学, 2012.
[20]	刘犇. BDNF与TrkB蛋白在小鼠子宫和着床前胚胎中表达规律的研究[J]. 黑龙江畜牧兽医, 2018(7):9-11, 16,245-246. doi: 10.13881/j.cnki.hljxmsy.2017.08.0222. doi: 10.13881/j.cnki.hljxmsy.2017.08.0222
[21]	Kawamura K, Kawamura N, Fukuda J, et al. Regulation of preimplantation embryo development by brain-derived neurotrophic factor[J]. Dev Biol, 2007, 311(1):147-158. doi: 10.1016/j.ydbio.2007.08.026. doi: 10.1016/j.ydbio.2007.08.026 pmid: 17880937
[22]	Kawamura K, Kawamura N, Sato W, et al. Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival[J]. Endocrinology, 2009, 150(8):3774-3782. doi: 10.1210/en.2009-0213. doi: 10.1210/en.2009-0213 pmid: 19372195
[23]	Lim W, Bae H, Bazer FW, et al. Brain-derived neurotrophic factor improves proliferation of endometrial epithelial cells by inhibition of endoplasmic reticulum stress during early pregnancy[J]. J Cell Physiol, 2017, 232(12):3641-3651. doi: 10.1002/jcp.25834. doi: 10.1002/jcp.25834 pmid: 28150859
[24]	吴敏敏, 蒋立艳, 操思凡. BDNF 及其受体在多囊卵巢综合征大鼠中的表达[J]. 重庆医学, 2015, 44(23):3190-3194. doi: 10.3969/j.issn.1671-8348.2015.23.007. doi: 10.3969/j.issn.1671-8348.2015.23.007
[25]	张楚, 严为巧, 张雪, 等. 脑源性神经营养因子及其特异性高亲和力受体在颗粒细胞中的表达与多囊卵巢综合征患者卵泡发育的关系[J]. 中国妇幼保健, 2016, 31(5):1051-1054. doi: 10.7620/zgfybj.j.issn.1001-4411.2016.05.61. doi: 10.7620/zgfybj.j.issn.1001-4411.2016.05.61
[26]	Buyuk E, Seifer DB. Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility[J]. Fertil Steril, 2008, 90(5):1611-1615. doi: 10.1016/j.fertnstert.2007.08.085. doi: 10.1016/j.fertnstert.2007.08.085 pmid: 18222435
[27]	Russo N, Russo M, Daino D, et al. Polycystic ovary syndrome: brain-derived neurotrophic factor (BDNF) plasma and follicular fluid levels[J]. Gynecol Endocrinol, 2012, 28(4):241-244. doi: 10.3109/09513590.2011.613969. doi: 10.3109/09513590.2011.613969 pmid: 22420627
[28]	Czyzyk A, Filipowicz D, Podfigurna A, et al. Brain-derived neurotrophic factor (BDNF) plasma concentration in patients diagnosed with premature ovarian insufficiency (POI)[J]. Gynecol Endocrinol, 2017, 33(5):413-417. doi: 10.1080/09513590.2017.1290073. doi: 10.1080/09513590.2017.1290073 pmid: 28277119
[29]	余慧. PCOS、DOR患者卵泡液BDNF、TAC水平及对IVF-ET结局影响[D]. 长沙: 中南大学, 2010.
[30]	Liu P, Zhang X, Hu J, et al. Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency[J]. Am J Reprod Immunol, 2020, 84(4):e13292. doi: 10.1111/aji.13292. doi: 10.1111/aji.13292
[31]	Becker CM, Bokor A, Heikinheimo O, et al. ESHRE guideline: endometriosis[J]. Hum Reprod Open, 2022, 2022(2): hoac009. doi: 10.1093/hropen/hoac009. doi: 10.1093/hropen/hoac009
[32]	Huang F, Cao J, Liu Q, et al. MAPK/ERK signal pathway involved expression of COX-2 and VEGF by IL-1β induced in human endometriosis stromal cells in vitro[J]. Int J Clin Exp Pathol, 2013, 6(10):2129-2136.
[33]	Usui T, Naruo A, Okada M, et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells[J]. Acta Physiol(Oxf), 2014, 211(2):385-394. doi: 10.1111/apha.12249. doi: 10.1111/apha.12249
[34]	Farahani ZK, Taherianfard M, Naderi MM, et al. Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis[J]. Physiol Rep, 2021, 9(22):e15117. doi: 10.14814/phy2.15117. doi: 10.14814/phy2.15117
[35]	Kasheh Farahani Z, Taherianfard M, Naderi MM, et al. Assessing Pain Behavioral Responses and Neurotrophic Factors in the Dorsal Root Ganglion, Serum and Peritoneal Fluid in Rat Models of Endometriosis[J]. J Family Reprod Health, 2020, 14(4):259-268. doi: 10.18502/jfrh.v14i4.5210. doi: 10.18502/jfrh.v14i4.5210 pmid: 34054998
[36]	Wang S, Duan H, Li B, et al. BDNF and TrkB expression levels in patients with endometriosis and their associations with dysmenorrhoea[J]. J Ovarian Res, 2022, 15(1):35. doi: 10.1186/s13048-022-00963-9. doi: 10.1186/s13048-022-00963-9 pmid: 35300713
[37]	梁月凤, 黄秀敏, 温兰玲, 等. 血清脑源性神经营养因子与子宫内膜异位症临床分期及痛经的相关性[J]. 中华医学杂志, 2020, 100(10):771-774. doi: 10.3760/cma.j.cn112137-20191205-02659. doi: 10.3760/cma.j.cn112137-20191205-02659.
[38]	Lee HC, Lin SC, Wu MH, et al. Inhibiting NTRK2 signaling causes endometriotic lesion regression[J]. Reproduction, 2021, 161(1):11-19. doi: 10.1530/REP-20-0163. doi: 10.1530/REP-20-0163 URL