The Effects of Endocrine Disrupting Chemicals on Female Fertility and Outcomes of Assisted Reproductive Technolog

doi:10.12280/gjszjk.20230082

Abstract

Abstract:

Endocrine disrupting chemicals(EDC) are exogenous compounds, which can interfere with the hormones action and endocrine pathways, affect the development of female reproductive system and ovarian function, and therefore EDCs are associated with female infertility. Current research mainly focus on EDC exposure and its correlation with the different diseases of the endocrine axes. Studies have shown that EDCs affect female fertility by causing ovarian dysfunction, follicular development abnormality, endometrial receptivity reduction, and embryo quality decline, as well as the lowed clinical outcome of assisted reproduction in infertile women. Accumulating evidence in animal studies has provided important insights into the mechanism of EDC effects. This review summarizes some of the most common EDCs including pesticides, bisphenol A and phthalates, and the effects of EDCs on female fertility and clinical outcomes of assisted reproductive technology.

Key words: Endocrine disruptors, Pesticides, Diethylhexyl phthalate, Fertility, Reproductive techniques, assisted

DENG Mei-xiang, SHI Yi-zhu, FENG Lan-qing. The Effects of Endocrine Disrupting Chemicals on Female Fertility and Outcomes of Assisted Reproductive Technolog[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 304-309.

References 41

[1]	Ghosh A, Tripathy A, Ghosh D. Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human[J]. Proceedings of the Zoological Society, 2022, 75(1):16-30. doi: 10.1007/s12595-021-00412-3. doi: 10.1007/s12595-021-00412-3
[2]	Green MP, Harvey AJ, Finger BJ, et al. Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period[J]. Environ Res, 2021, 194:110694. doi: 10.1016/j.envres.2020.110694. doi: 10.1016/j.envres.2020.110694 URL
[3]	Arya S, Dwivedi AK, Alvarado L, et al. Exposure of U.S. population to endocrine disruptive chemicals (Parabens, Benzophenone-3, Bisphenol-A and Triclosan) and their associations with female infertility[J]. Environ Pollut, 2020, 265(Pt A):114763. doi: 10.1016/j.envpol.2020.114763. doi: 10.1016/j.envpol.2020.114763
[4]	Segal TR, Giudice LC. Before the beginning: environmental exposures and reproductive and obstetrical outcomes[J]. Fertil Steril, 2019, 112(4):613-621. doi: 10.1016/j.fertnstert.2019.08.001. doi: S0015-0282(19)31989-2 pmid: 31561863
[5]	Liu Y, He QK, Xu ZR, et al. Thiamethoxam Exposure Induces Endoplasmic Reticulum Stress and Affects Ovarian Function and Oocyte Development in Mice[J]. J Agric Food Chem, 2021, 69(6):1942-1952. doi: 10.1021/acs.jafc.0c06340. doi: 10.1021/acs.jafc.0c06340 URL
[6]	Song J, Ma X, Li F, et al. Exposure to multiple pyrethroid insecticides affects ovarian follicular development via modifying microRNA expression[J]. Sci Total Environ, 2022, 828:154384. doi: 10.1016/j.scitotenv.2022.154384. doi: 10.1016/j.scitotenv.2022.154384 URL
[7]	Zhang Y, Ji L, Hu Y, et al. Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women[J]. Am J Epidemiol, 2020, 189(5):375-383. doi: 10.1093/aje/kwz242. doi: 10.1093/aje/kwz242 pmid: 31845721
[8]	Wu Y, Weng X, Liu S, et al. Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015-2018 National Health and Nutrition Examination Survey[J]. Environ Sci Pollut Res Int, 2023, 30(9):23411-23421. doi: 10.1007/s11356-022-23624-2. doi: 10.1007/s11356-022-23624-2
[9]	Björvang RD, Hallberg I, Pikki A, et al. Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies[J]. Environ Res, 2022, 208:112626. doi: 10.1016/j.envres.2021.112626. doi: 10.1016/j.envres.2021.112626 URL
[10]	Hu P, Vinturache A, Li H, et al. Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China[J]. Environ Health Perspect, 2020, 128(9):97007. doi: 10.1289/EHP7076. doi: 10.1289/EHP7076 URL
[11]	Chiu YH, Williams PL, Gillman MW, et al. Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology[J]. JAMA Intern Med, 2018, 178(1):17-26. doi: 10.1001/jamainternmed.2017.5038. doi: 10.1001/jamainternmed.2017.5038 URL
[12]	Al-Saleh I, Coskun S, El-Doush I, et al. Outcome of in-vitro fertilization treatment and DDT levels in serum and follicular fluid[J]. Med Sci Monit, 2009, 15(11):BR320-BR333.
[13]	Mahalingaiah S, Missmer SA, Maity A, et al. Association of hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene(DDE) with in vitro fertilization (IVF) outcomes[J]. Environ Health Perspect, 2012, 120(2):316-320. doi: 10.1289/ehp.1103696. doi: 10.1289/ehp.1103696 URL
[14]	Radwan P, Wielgomas B, Radwan M, et al. Synthetic Pyrethroids Exposure and Embryological Outcomes: A Cohort Study in Women from Fertility Clinic[J]. Int J Environ Res Public Health, 2022, 19(9):5117. doi: 10.3390/ijerph19095117. doi: 10.3390/ijerph19095117 URL
[15]	Colorado-Yohar SM, Castillo-González AC, Sánchez-Meca J, et al. Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis[J]. Sci Total Environ, 2021, 775:145755. doi: 10.1016/j.scitotenv.2021.145755. doi: 10.1016/j.scitotenv.2021.145755 URL
[16]	Ruiz T, Grigio V, Ferrato LJ, et al. Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females[J]. Mol Cell Endocrinol, 2023,566-567:111892. doi: 10.1016/j.mce.2023.111892. doi: 10.1016/j.mce.2023.111892
[17]	Khaghani AJ, Farrokh P, Zavareh S. Epigenetic effects of Bisphenol A on granulosa cells of mouse follicles during in vitro culture: An experimental study[J]. Int J Reprod Biomed, 2021, 19(2):129-136. doi: 10.18502/ijrm.v19i2.8471. doi: 10.18502/ijrm.v19i2.8471 pmid: 33718757
[18]	Fan H, Fernando SR, Jiang L, et al. Bisphenol A Analogues Suppress Spheroid Attachment on Human Endometrial Epithelial Cells through Modulation of Steroid Hormone Receptors Signaling Pathway[J]. Cells, 2021, 10(11):2882. doi: 10.3390/cells10112882. doi: 10.3390/cells10112882 URL
[19]	Caserta D, Costanzi F, De Marco MP, et al. Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies[J]. Int J Environ Res Public Health, 2021, 18(13):6840. doi: 10.3390/ijerph18136840. doi: 10.3390/ijerph18136840 URL
[20]	Nelson W, Adu-Gyamfi EA, Czika A, et al. Bisphenol A-induced mechanistic impairment of decidualization[J]. Mol Reprod Dev, 2020, 87(8):837-842. doi: 10.1002/mrd.23400. doi: 10.1002/mrd.23400 pmid: 32691498
[21]	Pan MH, Wu YK, Liao BY, et al. Bisphenol A Exposure Disrupts Organelle Distribution and Functions During Mouse Oocyte Maturation[J]. Front Cell Dev Biol, 2021, 9:661155. doi: 10.3389/fcell.2021.661155. doi: 10.3389/fcell.2021.661155 URL
[22]	Yang L, Baumann C, De La Fuente R, et al. Mechanisms underlying disruption of oocyte spindle stability by bisphenol compounds[J]. Reproduction, 2020, 159(4):383-396. doi: 10.1530/REP-19-0494. doi: 10.1530/REP-19-0494 pmid: 31990668
[23]	Vessa B, Perlman B, McGovern PG, et al. Endocrine disruptors and female fertility: a review of pesticide and plasticizer effects[J]. F S Rep, 2022, 3(2):86-90. doi: 10.1016/j.xfre.2022.04.003. doi: 10.1016/j.xfre.2022.04.003
[24]	Mok-Lin E, Ehrlich S, Williams PL, et al. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF[J]. Int J Androl, 2010, 33(2):385-393. doi: 10.1111/j.1365-2605.2009.01014.x. doi: 10.1111/j.1365-2605.2009.01014.x pmid: 20002217
[25]	Radwan P, Wielgomas B, Radwan M, et al. Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic[J]. Reprod Toxicol, 2020, 96:216-220. doi: 10.1016/j.reprotox.2020.07.009. doi: S0890-6238(20)30183-0 pmid: 32721521
[26]	Shen J, Kang Q, Mao Y, et al. Urinary bisphenol A concentration is correlated with poorer oocyte retrieval and embryo implantation outcomes in patients with tubal factor infertility undergoing in vitro fertilisation[J]. Ecotoxicol Environ Saf, 2020, 187:109816. doi: 10.1016/j.ecoenv.2019.109816. doi: 10.1016/j.ecoenv.2019.109816 URL
[27]	Mina A, Boutzios G, Papoutsis I, et al. Bisphenol A correlates with fewer retrieved oocytes in women with tubal factor infertility[J]. Hormones(Athens), 2022, 21(2):305-315. doi: 10.1007/s42000-022-00370-1. doi: 10.1007/s42000-022-00370-1
[28]	Mínguez-Alarcón L, Gaskins AJ, Chiu YH, et al. Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic[J]. Hum Reprod, 2015, 30(9):2120-2128. doi: 10.1093/humrep/dev183. doi: 10.1093/humrep/dev183 URL
[29]	Kim HK, Ko DH, Lee W, et al. Body fluid concentrations of bisphenol A and their association with in vitro fertilization outcomes[J]. Hum Fertil(Camb), 2021, 24(3):199-207. doi: 10.1080/14647273.2019.1612104. doi: 10.1080/14647273.2019.1612104
[30]	Basso CG, de Araújo-Ramos AT, Martino-Andrade AJ. Exposure to phthalates and female reproductive health: A literature review[J]. Reprod Toxicol, 2022, 109:61-79. doi: 10.1016/j.reprotox.2022.02.006. doi: 10.1016/j.reprotox.2022.02.006 pmid: 35248714
[31]	Wang JJ, Tian Y, Li MH, et al. Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly[J]. Theranostics, 2021, 11(10):4992-5009. doi: 10.7150/thno.55006. doi: 10.7150/thno.55006 URL
[32]	Liu JC, Xing CH, Xu Y, et al. DEHP exposure to lactating mice affects ovarian hormone production and antral follicle development of offspring[J]. J Hazard Mater, 2021, 416:125862. doi: 10.1016/j.jhazmat.2021.125862. doi: 10.1016/j.jhazmat.2021.125862 URL
[33]	Meling DD, Warner GR, Szumski JR, et al. The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice[J]. Toxicol Appl Pharmacol, 2020, 388:114875. doi: 10.1016/j.taap.2019.114875. doi: 10.1016/j.taap.2019.114875 URL
[34]	Pocar P, Fiandanese N, Secchi C, et al. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring[J]. Endocrinology, 2012, 153(2):937-948. doi: 10.1210/en.2011-1450. doi: 10.1210/en.2011-1450 pmid: 22147016
[35]	Lu Z, Zhang C, Han C, et al. Plasticizer Bis(2-ethylhexyl) Phthalate Causes Meiosis Defects and Decreases Fertilization Ability of Mouse Oocytes in Vivo[J]. J Agric Food Chem, 2019, 67(12):3459-3468. doi: 10.1021/acs.jafc.9b00121. doi: 10.1021/acs.jafc.9b00121 URL
[36]	Absalan F, Saremy S, Mansori E, et al. Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model[J]. Cell J, 2017, 18(4):503-513. doi: 10.22074/cellj.2016.4717. doi: 10.22074/cellj.2016.4717 pmid: 28042535
[37]	Hauser R, Gaskins AJ, Souter I, et al. Urinary Phthalate Metabolite Concentrations and Reproductive Outcomes among Women Undergoing in Vitro Fertilization: Results from the EARTH Study[J]. Environ Health Perspect, 2016, 124(6):831-839. doi: 10.1289/ehp.1509760. doi: 10.1289/ehp.1509760 URL
[38]	Al-Saleh I, Coskun S, Al-Doush I, et al. Couples exposure to phthalates and its influence on in vitro fertilization outcomes[J]. Chemosphere, 2019, 226:597-606. doi: 10.1016/j.chemosphere.2019.03.146. doi: S0045-6535(19)30592-2 pmid: 30954894
[39]	Machtinger R, Gaskins AJ, Racowsky C, et al. Urinary concentrations of biomarkers of phthalates and phthalate alternatives and IVF outcomes[J]. Environ Int, 2018, 111:23-31. doi: 10.1016/j.envint.2017.11.011. doi: S0160-4120(17)31513-1 pmid: 29161633
[40]	Bellavia A, Zou R, Björvang RD, et al. Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia[J]. Environ Res, 2023, 216(Pt 1):114447. doi: 10.1016/j.envres.2022.114447. doi: 10.1016/j.envres.2022.114447 URL
[41]	Deng T, Du Y, Wang Y, et al. The associations of urinary phthalate metabolites with the intermediate and pregnancy outcomes of women receiving IVF/ICSI treatments: A prospective single-center study[J]. Ecotoxicol Environ Saf, 2020, 188:109884. doi: 10.1016/j.ecoenv.2019.109884. doi: 10.1016/j.ecoenv.2019.109884 URL