Abstract: With the increasing technology in vitro fertilization-embryo transfer（IVF-ET）, the roles of cytokines in the regulation of oocyte development in ovarian microenvironment have been widely concerned. Cytokines as a class of hormone-like peptides with comprehensive biological activity participate in the regulation of reproduction, such as the follicular development, embryo development and blastocyst implantation and others, by regulating ovarian hormones and paracrine. It was found that the abnormal expression of cytokine profile in follicular fluid, such as vascular endothelial growth factor（VEGF）, granulocyte colony stimulating factor（G-CSF）, reactive oxygen species（ROS）, insulin-like growth factor（IGF）, interleukin（IL）, and leukemia inhibitory factor（LIF） could be related to the follicular mature disturbance. The enhancing research in this area will be helpful to improve the clinical pregnancy outcomes of IVF-ET.

Key words: Follicular fluid, Cytokines, Ovarian follicle, Pregnancy outcome