Abstract: Objective：To study the pregnancy outcome after selective fetal reduction in bichorionic twin pregnancies complicated by extremely preterm premature rupture of membranes in one sac, its main purpose is to provide some clinical data for the treatment of patients with very early premature rupture of membranes. Methods: This is a retrospective study of 6 patients who underwent selective fetal reduction for multiple gestations at the Reproductive Center of Renmin Hospital of Wuhan University from January 2012 to February 2018. All patients were conceived by IVF or ICSI. Results: Selective fetal reduction was performed successfully in 6 cases. One of six abnormal fetuses was the right one, one case was the left and the rest was lower fetus. The fluid breakage occurred within 24 hours and stopped within 8 days after fetal reduction. One women had oligohydramnios in the third trimester, one patient occurred premature rupture of premature rupture of membranes, and one patient had gestational diabetes mellitus during pregnancy. Of the 6 patients who underwent selective fetal reduction, one had preterm labor at 34+6 gestation weeks, while the other 5 were full-term delivery, of which 4 patients had cesarean section and 2 patients had vaginal birth. The six neonatal weight was 2 200-3 400 g, 4 were male infants, while 2 were female. Except for premature infants with lung infection, the other newborns had no complications. Conclusions: It recommends to expectant treatment for patients of dichorionic twins complicated by extremely preterm premature rupture of membranes of one sac performed selective fetal reduction. However, large sample studies are still needed to confirm this conclusion.

Key words: Reproductive techniques, assisted, Twins, dizygotic, Selective fetal reduction, Pregnancy outcome