Abstract: Smooth endoplasmic reticulum aggregates (SERA) refers to the abnormal oocytes smooth endoplasmic reticulum gather into a cluster. During assisted reproduction, it can occur in any type of ovulatory cycle. Studies have shown that SERA has certain negative effects on the fertilization rate of oocytes, blastocyst formation rate of embryos and pregnancy outcome. But there is debate about whether and to what extent this effect exists. Therefore, this paper reviews the research progress of oocyte smooth endoplasmic reticulum aggregation. Systematic research on the causes, results and remedies of SERA can help fertility doctors better deal with the occurrence of SERA in clinical work.

Key words: Endoplasmic reticulum, smooth；, Oocytes；, Reproductive techniques, assisted；, Fertilization；, Blastula；, Pregn；, Smooth endoplasmic reticulum aggregatess