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Table of Content

    15 May 2020, Volume 39 Issue 3
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    Establishment of A Standardized Training Programme for Senior Embryologists in China
    CAI Ling-bo,YAN Zheng-jie,CUI Yu-gui,LIU Jia-yin
    2020, 39 (3):  181-184. 
    Abstract ( 1883 )   PDF (610KB) ( 9121 )  
    The embryonic laboratory is the center department of clinical reproductive center, and the skill level of the embryologist is directly related to the success rate and safety of assisted reproductive technology (ART). The development of ART scale and the discipline construction of human embryology in China urgently need to train a group of competent senior embryologists. To be a qualified embryologist, just has knowledge and experience from formal education in university is not enough up to the requirement of job, more important is through the strict professional training, to obtain qualification certificate. At present, there is no training, examination and certification system for professional embryologists in China. With reference to international and domestic professional standards and guidelines, and through more than 10 years of practice and improvement, we set up an IVF simulation laboratory used for training of senior embryologists of human embryology, also we established a complete assessment system for embryologists to assess the technical operation and performance of clinical embryologists. Through the above methods, we can monitor and assess the competency of the embryologist. And the stability and safety of assisted reproductive technology treatment are guaranteed. The establishment of human embryologist standardization training system will provide reference for the training mode of senior embryologists in China, which is more conducive to the healthy and rapid development of the assisted reproduction technology.
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    The Application of Perfusion of Granulocyte Colony-Stimulating Factor in the Uterine Cavity Combined with Low Molecular Weight Heparin Injection in FET Women with Thin Endometrium
    BAI Chun-mei,TU Zeng-rong,WANG Li-yuan,DUAN Rui-yun
    2020, 39 (3):  185-189. 
    Abstract ( 1510 )   PDF (698KB) ( 9640 )  
    Objective: To investigate the clinical effect of intrauterine perfusion of the granulocyte colony-stimulating factor (G-CSF) combined with low molecular weight heparin (LMWH) on the clinical outcomes of freeze-thaw embryo transfer (FET) in those patients with thin endometrium. Methods: A total of 175 patients with thin endometrium who received FET in the First Hospital of Shanxi Medical University from June 2018 to October 2019 were selected and divided into 3 groups. Group A: 63 patients only received hormone replacement therapy as the control group. Group B: 52 patients received hormone replacement therapy and intrauterine G-CSF perfusion. Group C: 60 patients received hormone replacement therapy and intrauterine G-CSF perfusion and subcutaneous injection of LMWH. Endometrial thickness, endometrial blood flow resistance index (RI), pulse index (PI), cycle cancellation rate, embryo implantation rate, clinical pregnancy rate, early abortion rate, ectopic pregnancy rate and other indicators of the three groups were compared. Results: On the endometrial conversion day, of endometrial thickness, type Ⅱ+Ⅲ blood flow type rate in the group B and C were significantly increased when compared with group A, while RI and PI in the group B and C were significantly lower (all P<0.05). The embryo implantation rate, clinical pregnancy rate and cycle cancellation rate in the group B and C were significantly reduced when compared with group A (P<0.05), and there were no significant differences between the group B and C (P>0.05). The early abortion rate in the group C was significantly lower than that in the group B (P<0.05). Conclusions: Intrauterine perfusion of G-CSF during the FET cycle can significantly improve the endometrial thickness of patients with thin endometrium, the blood flow of endometrium, the embryo implantation rate and clinical pregnancy rate. The combined LMWH injection can reduce the early abortion rate.
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    Differentiation of Human Embryonic Stem Cell to Endometrium-Like Cell: A Pilot Study
    GUO Shan,YUAN Tao,LIU Ying
    2020, 39 (3):  190-194. 
    Abstract ( 1355 )   PDF (7538KB) ( 8994 )  
    Objective: To explore the differentiation methods of the feeder-free cultured human embryonic stem cell (hESCs) to human endometrium-like cell. Methods:The hESCs were differentiated in vitro using the co-cultured method and the cytokine-induced method. Flow cytometry was applied to detect the differentiation efficiency of hESCs by human endometrium epithelial marker cytokeratin-18(CK-18) and human endometrium mesenchymal marker vimentin(VIM). Results:The hESCs cultured with the two methods represented the elongated and spindle shape on day7. Flow cytometry analysis on day 8 showed that the differentiated cells were all negative for vimentin and partially positive for CK-18. Compared to the cytokine-induced method, the co-cultured method obtained more endometrium epithelial-like cells [(55.63±10.29)% vs. (13.9±0.26)%, P<0.05]. Conclusions:hESCs were successfully induced to differentiate to endometrium epithelial-like cells by both the co-cultured method and the cytokine-induced method. Compared to the cytokine-induced method, the co-cultured method can obtain endometrium epithelial-like cells more efficiently.
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    2020, 39 (3):  194-194. 
    Abstract ( 1531 )   PDF (158KB) ( 9067 )  
     
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    Analysis of Related Factors of Villous Chromosome Abnormality in Artificial Insemination and Spontaneous Abortion in Early Natural Pregnancy
    GUO Li-na,LIU Pan,ZHAO Min-ying,LIAO Ying,SU Ya-qin,TIAN Yu
    2020, 39 (3):  195-198. 
    Abstract ( 1481 )   PDF (626KB) ( 9103 )  
    Objective: To investigate the chromosome abnormalities in early spontaneous abortion villi of artificial intrauterine insemination (AIH) pregnancy and natural pregnancy, as well as the effect of the related factors of assisted reproduction on above chromosome abnormalities. Methods:The clinical data of 104 patients with early spontaneous abortion in our hospital from January 2017 to December 2019 were retrospectively analyzed, including 27 in the AIH group and 77 in the natural pregnancy group. All abortion villous samples were tested for karyotype. The incidences of chromosome abnormalities in the two groups were compared. The effects of female age and AIH assisted pregnancy on the chromosome abnormalities were investigated. Results:The total rate of chromosome abnormalities in early abortion villi was 52.88% (55/104), of which the chromosome number abnormality accounted for 94.55% (52/55). There was no significant difference in the incidence of chromosome abnormalities between the two groups ( χ2=0.010, P=0.921). The patients in the two groups were sub-grouped according to their ages <25 years, 25-29 years, 30-34 years and ≥35 years, individually. There was significant difference in the rate of villous chromosome abnormalities among the aged-subgroups of the AIH group and the natural pregnancy group (all P<0.05). However, there were no significant differences between the corresponding aged-subgroups of the two groups(P=1.00). In the 27 cases of AIH early abortion, 15 cases had villous chromosome abnormalities. Conclusions:AIH does not increase the chromosome abnormalities in early spontaneous abortion villi, and patients with spontaneous abortion should promptly find the causes of abortion. AIH can be recommended for those infertile patients with the AIH-related indications.
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    Analysis of Pregnancy Outcomes after Transvaginal Reduction of Triple Pregnancies with Monozygotic Twins
    DING Hui,LING Xiu-feng,LI Xiu-ling,ZHAO Chun,LU Ying,ZHANG Juan,XIE Qi-jun,CHEN Xiao-yan,WANG Pei
    2020, 39 (3):  198-201. 
    Abstract ( 1452 )   PDF (608KB) ( 9027 )  
    Objective: To explore the pregnancy outcomes after the reduction of triple pregnancies with monozygotic twins (MZT). Methods:A total of 47 cases of transvaginal reduction due to monozygotic(MZ)-triplets and 45 cases of transvaginal reduction due to non-MZ triplets in our Reproductive Center from January 2009 to December 2018 were retrospectively analyzed. The live birth rate, term birth rate, premature birth rate, early abortion rate, late abortion rate, the rate of the survival of one baby, the rate of the survival of two babies, gestational week of birth, neonatal birth weight and the incidence of low birth weight were compared between the two groups. Results:(1)The rate of premature birth and the rate of survival of two babies were decreased in the MZ-triplet group when compared with the non-MZ triplet group, and the rate of survival of one baby was increased(all P<0.05). (2) In 47 cases of MZ-triplet group, 16 cases were performed the embryonic reduction of single-egg single-embryo, and 31 cases were performed the embryonic reduction of one of MZ-twins embryos. Compared with 16 cases of the embryonic reduction of single-egg single-embryo, the rate of the survival of one baby and neonatal birth weight in 31 cases of the embryonic reduction of one embryo MZ-twins embryos were increased, while the incidences of the survival of two babies and low birth weight infant were decreased(all P< 0.05). Conclusions:Transvaginal reduction of one of MZ-twins embryos in those triple-pregnancies with MZT is feasible and easier to obtain the outcome of single pregnancy.
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    Clinical Genetic Characteristics of Imbalanced Translocation between Xp/Yq Chromosomes
    CAI Chan-hui, LI Yi, HU Jing-jing, LI Xing, LI Xian-zheng
    2020, 39 (3):  202-206. 
    Abstract ( 1505 )   PDF (1875KB) ( 9137 )  
    Objective: To investigate the clinical genetic characteristics of imbalanced translocation between Xp/Yq chromosomes. Methods:The imbalanced translocation between Xp/Yq chromosomes was analyzed by chromosome karyotype and chromosomal microarray. The cytogenetic analysis was also performed in members of relevant family. Results:Chromosomal microarray analysis (CMA) and karyotype analysis confirmed the 46,Y,der(X)t(X;Y)(p22.3;q11.22) with the lack of Xp22.33-p22.31 and the repeat of Yq11.221-q11.23. The karyotype of the father is normal, while the karyotype of the mother is 46,X,der(X)t(X;Y)(p22.3;q11.22). The results of the elder brother were consistent with those of the fetus. Conclusions:The abnormal chromosome of this fetus is maternal, most of the female patients could have no more clinical manifestations except short stature, while male patients often have the complex clinical phenotypes of Xp contiguous gene syndrome. The combined application of chromosome karyotype and chromosomal microarray analysis can provide more comprehensive and accurate genetic basis for prenatal diagnosis, clarify the genetic etiology, and guide the fertility.
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    The Value of Ultrasound Diagnosis of Conjoined Twins Malformation in Early Pregnancy
    ZHOU Xun-dan,HOU Xiao-xia,ZHANG Wen-ting,YANG Fang,AN Pei-li,GAO Xin-ru
    2020, 39 (3):  207-209. 
    Abstract ( 1362 )   PDF (2645KB) ( 9067 )  
    Objective: To analyze the characteristics of ultrasound images of conjoined twins malformation in early pregnancy, and to improve the accuracy of ultrasound diagnosis of conjoined twin-fetuses. Methods: This is a retrospective analysis of 16 cases of conjoined twin-fetuses diagnosed by ultrasound in Northwest Women and Children′s Hospital and confirmed by follow-up. Two-dimensional ultrasound was used to observe the connection site, organ sharing and fusion degree of conjoined fetuses. Results: In 16 conjoined twins, there were 11 cases(68.75%) of parapagus dicephalus, 7 cases of thoracoperitoneal joint, 2 cases of thoracoperitoneal and sacrococcygeal joint, and 2 cases of only abdominal joint. In 4 cases(25.00%)of craniopagus,there were 2 cases of combined thoracoperitoneal joint,2 case of head joint;1 case(6.25%)of ischiopagus. Among all the cases, 5 cases were combined with other malformations, including 2 cases with neck hydrocyst tumor(1 case twins combined heart malformation), 1 case with leafless whole forebrain, 1 case with upper limb radial absence, and 1 case with small jaw. Conclusions: For conjoined twin fetuses,diagnosis and termination of pregnancy should be done as soon as possible. Ultrasonography can directly show the position, common organs, degree of fusion and concomitant deformity of the conjoined fetus in the amniotic cavity,which is of great significance for judging the prognosis.
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    Current Status of Human Papillomavirus Vaccination in Women of Fertile Age and Its Related Factors
    YUAN Li,CHU Ai-qin,XU An-lan,ZHANG Peng-nian,CHU Xia-fei
    2020, 39 (3):  210-212. 
    Abstract ( 1456 )   PDF (474KB) ( 8940 )  
    Objective: To understand the current situation of human papillomavirus (HPV) vaccination in reproductive-aged women and its factors in Anhui, China. Methods: 417 women undergoing the physical examination were surveyed by convenient sampling method in our hospital from April 2019 to May 2019. A self-made structured questionnaire was used to investigate the general information, the status of HPV vaccination, knowledge of HPV vaccination and awareness of vaccination. Results: 7.19% (30/417) women received HPV vaccination. 57.07% (238/417) women indicated willingness to vaccinate. Education level, occupation, understanding and recognition of HPV vaccine and awareness of vaccination are related to the situation of HPV vaccination. Conclusions: It is necessary to promote the health education on HPV vaccination for reproductive-aged women and to improve their knowledge of HPV vaccine and awareness of vaccination.
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    Predication of Gestational Diabetes by Glycated Hemoglobin and PAPP-A in Early Pregnancy
    XIE Huan, ZHANG Nan, GUO Yu-wen
    2020, 39 (3):  213-218. 
    Abstract ( 1485 )   PDF (3098KB) ( 9122 )  
    Objective: To investigate the prediction of gestational diabetes mellitus (GDM) by serum glycohemoglobin (HbA1c) combined with pregnancy-associated plasma protein A (PAPP-A) in early pregnancy. Methods: The pregnant women were included from December 1, 2018 to July 30, 2019. Clinical data, fasting plasma glucose (FPG),HbA1c and PAPP-A median multiple of the median (MoM) were collected in early pregnancy (11 to 13+6 weeks). Based on a 75 g oral glucose tolerance test (OGTT) at 24 to 28 weeks, the pregnant women were divided into the study group and the control group. The optimal cutoff value of GDM was predicted by the statistical analysis, so as to get an optimal scheme to predict GDM in early pregnancy. Results: Multivariate logistic regression analysis showed that the independent risk-factors for GDM could include the high levels of FPG and HbA1c,low level of PAPP-A,pregnancy with assisted reproduction technology, family history of diabetes,and overweight or obesity in early pregnancy. The risk of GDM in the women with the family history of diabetes or in those pregnanct women with assisted reproduction technology was significantly increased (OR were 7.206 and 47.512, both P<0.001). Analysis of receiver operating characteristic (ROC) curves and area under the curve (AUC) as different predictive indicators showed that the PAPP-A MoM combined with HbA1c and FPG had the highest AUC (0.728),and there after the PAPP-A MoM combined with HbA1c (0.721) and the HbA1c combined with FPG (0.717), were both larger than HbA1c (0.707) and FPG (0.647) . The single AUC of PAPP-A MoM (0.380) was meaningless for the diagnosis of GDM. Conclusions: The combined detection of HbA1c and PAPP-A MoM can be recommended for those pregnancy women with high-risk factors to predict GDM in the early pregnancy.
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    Environmental Endocrine Disruptors and Premature Ovarian Insufficiency
    WEN Xin,ZHANG Yue-hui,YAO Mei-yu
    2020, 39 (3):  219-225. 
    Abstract ( 1253 )   PDF (1199KB) ( 9240 )  
    More and more evidences suggest that early life exposure to environmental endocrine disruptors (EEDs) can cause the change of ovarian structure and function, following adult reproductive dysfunction. Premature ovarian insufficiency (POI) is a heterogeneous disease with complex and diverse etiologies, 75%-90% of which are unknown idiopathic POI. The epigenetic modification and environmental factors have been identified to cause reproductive damage. Human even from embryo is widely exposed to environmental EEDs, and EEDs can have a lifelong impact on female reproduction. In this paper, the four windows of ovarian sensitivity to EEDs(included PGCs sdevelopment, Meiosis, PFs formation,follicles recruitment), and the mechanism of EEDs related to POI were reviewed.
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    The Research Progress of the Primordial Follicle Activation and Folliculogenesis
    MAO Jing-qin,MAO Yun-dong
    2020, 39 (3):  225-228. 
    Abstract ( 1490 )   PDF (562KB) ( 9081 )  
    Primordial follicles have been formed before birth in mammals, and the reserve in follicle pool no longer increase after birth. With the activation of the primordial follicles, the follicles which were originally dormant gradually enter the growth stage, and gradually evolve from primary follicles and secondary follicles to antral follicles. Ovulation occurs in the dominant follicles with the stimulation of gonadotropins. Oocyte-derived and exogenous factors which regulate the maturation of oocytes, the proliferation and differentiation of the cells and granulosa cells through paracrine, autocrine, and endocrine ways. Besides, the communication between oocytes and granulosa cells through gaps junction allows synchronous development of all compartments of the follicle to maintain the follicle integrity. The thorough research on the mechanism of follicle activation and folliculogenesis will be beneficial to the solution of oocyte-related infertility in the field of reproductive medicine.
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    The Research Progress of Smooth Endoplasmic Reticulum Aggregates in Oocytes
    LIANG Qi,TANG Xiao-han,LU Mei-song
    2020, 39 (3):  229-232. 
    Abstract ( 1468 )   PDF (549KB) ( 9079 )  
    Smooth endoplasmic reticulum aggregates (SERA) refers to the abnormal oocytes smooth endoplasmic reticulum gather into a cluster. During assisted reproduction, it can occur in any type of ovulatory cycle. Studies have shown that SERA has certain negative effects on the fertilization rate of oocytes, blastocyst formation rate of embryos and pregnancy outcome. But there is debate about whether and to what extent this effect exists. Therefore, this paper reviews the research progress of oocyte smooth endoplasmic reticulum aggregation. Systematic research on the causes, results and remedies of SERA can help fertility doctors better deal with the occurrence of SERA in clinical work.
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    Research Progress of GnRHa Down-Regulation Protocols in Frozen-Thawed Embryo Transfer
    XING Ya-chun,LING Xiu-feng,SU Yan,ZHAO Chun,ZHANG Jun-qiang
    2020, 39 (3):  233-237. 
    Abstract ( 1791 )   PDF (768KB) ( 9691 )  
    The frozen-thawed embryo transfer (FET) has been a widely used technique in the past decades, in which two key factors of a successful pregnancy are the well-potential embryo the well-prepared endometrium. The protocols of endometrial preparation include natural cycle (NC), hormone replacement treatment cycle (HRT), controlled ovarian stimulation cycle (COS), and down-regulation plus HRT cycle. The down-regulation plus HRT cycle, also known as down-regulation artificial cycle, is a protocol of the endometrial preparation by adding exogenous estrogen after the pituitary down-regulation by using gonadotropin-releasing hormone agonist (GnRHa). GnRHa can regulate the pituitary gland by inhibiting the hypothalamic-pituitary-ovarian axis, avoid the uncontrolled follicular development and the elevated serum LH, and improve endometrial receptivity through energy metabolism and immune response. GnRHa can improve the pregnancy outcomes in people with endometriosis and adenomyosis, polycystic ovary syndrome, recurrent implantation failure, elevated progesterone in follicular phase, and thin endometrium.
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    Research Progress of Human Chorionic Gonadotropin Adminstration in Embryo Transfer
    ZHOU Yan-qiong,GUI Wen-wu
    2020, 39 (3):  237-241. 
    Abstract ( 1470 )   PDF (629KB) ( 9095 )  
    Although great progress has been made in assisted reproductive technology (ART) since the mid-1990s, the embryo implantation rate after transfer is relatively low. Embryo implantation is a complex process involving the interaction between the embryo and the endometrium. Among the many factors involved in implantation, human chorionic gonadotropin (hCG) plays a key role. As one of the early embryonic signals secreted by embryos before implantation, hCG mRNA began to transcribe as early as the embryonic 8-cell stage, while blastocysts began to express hCG before implantation. Studies have shown that hCG, as an important medium in the early stage of embryo implantation, promotes the endometrial decidualization, angiogenesis, trophoblast invasion and maternal immune tolerance by improving endometrial receptivity, which is beneficial to successful embryo implantation. In this paper, we summarize the application of human chorionic gonadotropin in embryo transfer and its research progress.
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    Current Situation of Induced Abortion Group and Related Reproductive Health Education
    ZHANG Qi,MA Xiu-hua,WANG Ying
    2020, 39 (3):  242-246. 
    Abstract ( 1360 )   PDF (769KB) ( 9052 )  
    Induced abortion is a remedy for female contraceptive failure,but it has a double-edged effect. In recent years,the rates of induced abortion and repeated induced abortion are both high,and there are differences in social demography,personal routine,reproductive health awareness and other factors among the population receiving induced abortion. The reasons of induced abortion are also different. The effective implementation and precise development of reproductive health education will exert an important impact on the current situation of induced abortion population. According to the comprehensive analysis of the current situation of induced abortion group and reproductive health education,it is found that the current rates of induced abortion and repeated induced abortion in China are still at high levels,and the time of the first sexual behavior and the group receiving induced abortion have shown the trend of low-age development. There is no significant correlation between the level of education and the occurrence of induced abortion. The main reason of induced abortion is still the very low utilization rate of long-term and reversible contraceptive measures. Meanwhile,the proportion of people without contraception is increasing year by year. Men′s effective participation in reproductive health is still low. Health education and the post abortion care (PAC) program can effectively reduce the incidence of unwanted pregnancy,and further reduce the rates of induced abortion and repeated abortion.
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    Research Progress on the Relationship between Early Threatened Abortion and Carbohydrate Antigen 125
    WANG Chun-qiao,ZHENG Jing
    2020, 39 (3):  247-250. 
    Abstract ( 1370 )   PDF (590KB) ( 9033 )  
    The incidence of early threatened abortion is increasing, which is one of the major obstetric diseases of particular concern. It is important that obstetrician should focus on the monitoring and treatment of early threatened abortion. After reviewing literatures, we found that the important roles of carbo hydrate antigen 125 (CA125) in early threatened abortion have been raised more and more concern. Serum CA125 may be one of the predictors and diagnostic markers of early threatened abortion. Many drugs such as progesterone, didroxyprogesterone and human chorionic gonadotropin can effectively improve the pregnancy success rate and reduce the level of serum CA125. Based on different mechanism, these drugs can be tried in different patients. However, there is no unified statement on the relationship between early threatened abortion and serum CA125, and the related basic values and thresholds of CA125 in early threatened abortion are not clear. Relevant details need further study.
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    Progress in the Diagnosis and Treatment of Caesarean Scar Pregnancy
    MA Yuan, ZHANG Guang-mei
    2020, 39 (3):  251-256. 
    Abstract ( 1338 )   PDF (977KB) ( 9086 )  
    Caesarean scar pregnancy (CSP) is a type of ectopic pregnancy, which is an abnormal and life-threatening embryo implantation form. During early pregnancy, the fertilized egg is implanted in the scar of the previous uterine incision of cesarean section. With the opening universal two-child policy in our country, and with the development of transvaginal ultrasonography, the frequency of CSP diagnoses has increased as well. People′s understanding of CSP is also more profound. Clinical manifestations of CSP are various, even one third of CSP patients are asymptomatic at the time of diagnosis, as many as 10% of CSP cases could be initially misdiagnosed. Although there is no consensus on the best treatment plan and management guidelines for CSP, the treatment objectives basically include the following four points:to terminate pregnancy, to reduce bleeding, to prevent uterine rupture and to preserve fertility. Management options include expectant, medication, uterine artery embolization (UAE), surgery and a combination approach. In this review, we discuss the prevalence, diagnostic criteria, and clinically available treatment options of CSP.
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    High-Intensity Focused Ultrasound Ablation for Uterine Leiomyoma in A Pregnant Woman: A Case Report and Literature Review
    WANG Yu-mei,LI Shuang-di,WANG Bei-ying,SHENG Qing-jing,WANG Hai-yun
    2020, 39 (3):  256-259. 
    Abstract ( 1333 )   PDF (5805KB) ( 9127 )  
    High-intensity focused ultrasound (HIFU) ablation for uterine leiomyoma, as a new non-invasive treatment, has been more and more widely used in the treatment of uterine leiomyoma. However, there are few literature reports on the early pregnancy and pregnancy outcome after the improper timing of HIFU treatment for uterine leiomyoma. We report a case of inappropriate timing of high-intensity focused ultrasound ablation for uterine leiomyoma in a pregnant woman,with literature review. We summarize the influence of uterine leiomyoma on pregnancy, the influence of different treatment methods on pregnancy, the timing of HIFU ablation for uterine leiomyoma, the problem of fetal retention when HIFU ablation for uterine leiomyoma combined with pregnancy, and the effect of HIFU ablation for uterine leiomyoma on abortion operation, etc. Even more important, we discuss the indication of HIFU ablation for uterine leiomyoma, the appropriate treatment time, and the appropriate pregnancy opportunity after HIFU operation.
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    A Case Report of the Diagnosis and Treatment of the Abdominal Compartment Syndrome after Radical Hysterectomy of Cervical Cancer
    CHEN Yu-ying,CUI Man-hua,HAN Gang,ZHANG Yue-lin,JIA Yan
    2020, 39 (3):  260-262. 
    Abstract ( 1467 )   PDF (472KB) ( 9028 )  
    Abdominal Compartment Syndrome(ACS) is a rare complication with a high death rate in laparotomy. We report a case of ACS complicated with incision dehiscence after radical resection of cervical malignant tumor, and emphasize the importance of accurate monitoring of intra-abdominal pressure and timely laparotomy in high-risk patients. This was a extremely obese patient, BMI=40 kg/m2. She was performed radical hysterectomy for cervical cancer (extensive abdominal hysterectomy, bilateral ovaries, bilateral oviducts ectomy, pelvic lymphadenectomy) after two rounds of neoadjuvant chemotherapy. On the first day after operation, the patient continued to suffer from abdominal distention and cough. ACS was found on the 4th day after operation and Laparotomy was timely performed. The postoperative recovery was good. After 10 months follow-up, there are no signs of complications.
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    Ovarian Cyst Pedicle Torsion Caused Recurrent Intestinal Obstruction for Five Years: A Case Report
    XU Hong-yan, TENG Xiu-xiang
    2020, 39 (3):  263-264. 
    Abstract ( 1473 )   PDF (778KB) ( 9039 )  
    Ovarian cyst pedicle torsion is a common gynecological acute abdominal disease. Intestinal obstruction caused by ovarian cyst pedicle torsion is very rare. Since this kind of situation is usually missed or misdiagnosed, patients may not get proper treatment immediately. This is a case report of intestinal obstruction caused by ovarian cyst pedicle torsion which was diagnosed in Beijing Hospital of Traditional Chinese Medicine. More attention should be given to this kind of cases.
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