Regulatory Role of N6-Methyladenosine Modification in Oogenesis and Early Embryonic Development

doi:10.12280/gjszjk.20230089

Abstract

Abstract:

N⁶-methyladenosine (m⁶A) refers to the methylation modification at the N⁶ position of adenosine in RNA, which is the most abundant epitranscriptomic modification in mammalian mRNA. m⁶A depends on the co-regulatory effects of methyltransferase (Writer), demethylase (Eraser) and m⁶A binding protein (Reader). Numerous studies have shown that m⁶A and its regulatory enzymes are present in the follicles and early embryonic tissues at all development stages, and that m⁶A is extensively involved in the mRNA metabolic processes by virtue of their dynamic, reversible and sensitive properties. Therefore, m⁶A participates in the regulation of oogenesis, nuclear reprogramming, lineage differentiation, implantation, and gestation maintenance of early embryos at the post-transcriptional level. Because m⁶A is largely related to female fertility and pregnancy outcome, m⁶A may be a new marker of diagnosis and prognosis of many reproductive diseases, or a potential therapeutic target.

Key words: RNA, messenger, Oogenesis, Embryonic development, Methylation

WEN Xin, ZHAO Xiao-li, LUAN Zu-qian, GAO Na, DONG Rong, XIA Tian. Regulatory Role of N⁶-Methyladenosine Modification in Oogenesis and Early Embryonic Development[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 310-316.

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Regulatory Role of N⁶-Methyladenosine Modification in Oogenesis and Early Embryonic Development

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