Research Progress on the Effect of Hypoxia on Endometriosis

doi:10.12280/gjszjk.20200560

Abstract

Abstract:

Endometriosis (EMs) is one of the most common gynecological diseases in women of childbearing age. It is a benign disease with malignant behavior and can occur in various parts of the body. There are many risk factors leading to EMs, including endocrine, genetic, environmental and immune factors. At present, the etiology of EMs is still unknown. Recent studies have shown that hypoxia is the driving force of EMs. Hypoxia can affect the occurrence and development of EMs in three aspects. (1) Hypoxia over-activates COX-2/PGE₂ and up-regulates steroid hormone-producing enzymes, thus promoting estrogen production; at the same time, hypoxia reduces the ratio of ERα to ERβ and PR, and changes the efficiency of steroids. (2) Hypoxia-activated angiogenic factors such as VEGF and Ang promote the rapid formation of blood vessels in ectopic lesions and provide oxygen and nutrients for the growth of ectopic lesions. (3) Hypoxia interferes with the normal autophagy process of EMs cells and promotes its invasion and metastasis. This paper reviews the pathogenesis and related treatment of hypoxia in EMs, in order to provide a new perspective for clinical diagnosis and treatment.

Key words: Endometriosis, Hypoxia, Neovascularization,pathologic, Estrogens, Autophagy

WANG Tian, ZHENG Jing-ying, PENG Yuan-qing, WANG Nan, ZHAO Shu-hua. Research Progress on the Effect of Hypoxia on Endometriosis[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 237-241.

Figures/Tables 1

References 32

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