Abstract: Objective：To assess the safety, effectiveness and acceptability of quinacrine sterilization(QS) when QS was cosmically used in clinic. Methods: This trial was completed from March 2007 to July2010. 6 000 female volunteers were recruited in Guizhou province. Seven pellets of QS (252 mg) were insertedinto uteri using the modified Cu-T intrauterine device (IUD) during days 3 to 7 after menstruation or >delivery/ postpartum 6 weeks. The second insertion of the same dose was performed 4 weeks of the first insertion.Questionnaires and physical examination were asked during the 3rd, 6th, 12th, and 24th months. Results: 5 780 cases were followed -up with the longest follow -up times,1248 days. The main side effects were yellow discharge from vagina, dizziness，tired, menstrual irregularity. There was not any serious side effect. The effective rate was 98.5% , which effected by the situation and time of QS insertion. Conclusions：QS wasachea, contraceptive with the characteristics of simple performance, non-wound and non-pain, low side effectand hign acceptability. Some factor can increase the QS effective rate, such as delivery / postpartum 6 weeks，3 to7 after menstruation，two times of insertion, lying down for 2 hours after QS procedure, contraceptive3 months after each insertion. QS contraceptive has positive role in improving acceptability of female sterilization and reducing cost of family planning.

Key words: Sterilization, reproductive, Female, Quinacrine, Non-surgical sterilization