Abstract: Suppressor of cytokine signaling 3（ＳＯＣＳ３）， ａ ｎｅｇａｔｉｖｅ ｆｅｅｄｂａｃｋ ｆａｃｔｏｒ ｏｆ ｓｉｇｎａｌｉｎｇ ｐａｔｈｗａｙｓ ｏｆ ｍａｎｙ ｃｙｔｏｋｉｎｅｓ（ｓｕｃｈ ａｓ ｉｎｔｅｒｌｅｕｋｉｎｓ， ｉｎｔｅｒｆｅｒｏｎｓ， ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ， ｅｔｃ．）， plays its suppressive roles mainly through activating the tyrosine kinase pathway and the JAK-STAT pathway. It was found that SOCS3 was involved in many diseases, such as diabetes, polycystic ovary syndrome, cancer, inflammatory, allergic reactions and many other diseases. So SOCS3 could be used as a molecular marker for the diagnosis and assessment of prognosis of those diseases, even as a potential target gene for some specific diseases.

Key words: Cytokines, Adaptor proteins, signal transducing, STAT transcription factors, Diabetes mellitus, Polycystic ovary syndrome, Neoplasms, Suppressor of cytokine signaling 3