Abstract: Objective：To detect the expressions of miRNA-29c，miRNA-30b and those predictive target genes in human endometrium and decidua tissues，and to explore their effects on decidualization of endometria. Methods：Tissue samples including 14 secretory endometria，16 early pregnancy deciduas and 18 spontaneous miscarriage deciduas were collected. Expressions of miRNA-29c and miRNA-30b were detected by quantitative real-time polymerase chain reaction（ｑＰＣＲ）. Expressions of two predicted target genes of miRNA-29c and ｍｉＲＮＡ－３０ｂ， ｓｅｒｕｍ ａｎｄ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄ－ｉｎｄｕｃｉｂｌｅ ｋｉｎａｓｅ １（ＳＧＫ１） ａｎｄ lｅｐｔｉｎ rｅｃｅｐｔｏｒ （ＬＥＰＲ）， ｗｅｒｅ ａｌｓｏ detected by qPCR. Results：The expression of miRNA-29c in the spontaneous miscarriage decidua tissues was higher than that in the secretory endometrial tissues（P＜0.05）. There were not significant differences in expressions of miRNA-30b among three groups（P＞0.05）. Moreover，expressions of SGK1 and LEPR mRNAs were at highest level in the early pregnancy deciduas，while they were at lowest level in the spontaneous miscarriage deciduas（P＜0.05）. Conclusions：Expression of miRNA-29c in endometrium may be associated with decidualization by targeting SGK1. Expressions of SGK1 and LEPR in deciduas tissue may be associated with maintaining early pregnancy.

Key words: MicroRNAs, Serum and glucocorticoid-inducible kinase 1, Receptors, leptin, Endometrium