Abstract: Objective： To evaluate the optimal operation method for the midtrimester termination of pregnancy in those women with systemic lupus erythematosus（SLE），and to investigate the family planning and midtrimester termination methods in those SLE women. Methods：A retrospective study was carried out on 34 cases with SLE who accepted mid-trimester induced abortion in Peking Union Medical College Hospital from Jan. 1994 to Apr. 2012. Results：There were 15（４４．１％） avoidable abortion cases with the reasons of social factors or unintended pregnancy during SLE treatment. There were 19（５５．９％) inevitable abortion cases. Main reasons included fetus factors，the first attack of SLE during pregnancy，SLE flare with planning pregnancy during the SLE stable period. The abortion methods included：3 cases with dilatation and evacuation in 12-16 weeks of pregnancy；Two cases with medical procedures with mifepristone plus misoprostol；■ cases with amniocentesis after injection of ethacridine into amniotic sac in 17-28 weeks of pregnancy；Four cases with cesarean section. There are no difference between two groups in pregnant week and method of abortion. Lupus flares during pregnancy of the inevitable group （16/19） was more than that of the evitable group（6/15，P＜0.05）. One massive hemorrhage happened in the dilatation and evacuation. There were no more complications. Conclusions：The midtrimester induced abortion was safe for SLE women under SLE well-controlled，but the operation should be valued as high risk. Those SLE patients should be given timely and accurate family planning guidance in case of those concomitant risks during unintended pregnancy.

Key words: Lupus erythematosus, systemic, Pregnancy trimester, second, Labor, induced, Contraception, Family planning services