Abstract: Objective: To explore the application of the low-dose human chorionic gonadotropin（hCG）combined with human menopausal gonadotropin（hMG） in ovulation induction for those patients with hypogonadotropic hypogonadism（HH）. Methods: 11 cases of HH（23 cycles total) received the low-dose hCG（100～200 IU/d） combined with hMG（150 IU/d） for ovulation induction from the fifth day of cycle, as the study group. 5 cases of HH (9 cycles total), as the control group, received only hMG（150 IU/d） for ovulation induction. Total dose of hMG，ovulation stimulate days，the number of oocyte with mean diameter ≥18 mm, the endometrium thickness on the day of induced ovulation and the pregnancy rate of induction cycle were compared. Results: ① There were not significant differences in age，BMI，the number of oocyte with mean diameter ≥18 mm, the endometrium thickness on the day of induced ovulation and the pregnancy rate of induction cycle between 2 groups（P＞0.05）.②Total dose of hMG in induction cycle in the study group was significantly lower than that in the control group[（1 829.35±625.35）IU vs. （2 408.33±263.69 IU），P＜0.05]. ③The continued days of ovulation induction in the study group were significantly less than those in the control group[（15.04±2.94）d vs.（22.89±1.96）d，P＜0.001]. Conclusions: The low-dose hCG combined with hMG in ovulation induction for patients with HH can decrease the dose of hMG and shorten the days of ovulation induction stimulate, with the high pregnancy rate of induction cycle.

Key words: Gonadotropins, Hypogonadism, Chorionic gonadotropin, Menotropins, Ovulation induction