Abstract: Objective: To analyse the clinical characteristics of those patients with poor ovarian response（POR） diagnosed according to the Bologna Criteria in IVF-ET, and compare the clinical outcomes of different ovarian stimulation protocols, so as to evaluate therapeutic schedules for POR patients. Methods：The clinical data of 186 cycles in 164 patients undergone IVF-ET in our center from December 2010 to October 2012 were retrospectively analyzed. Those cycles were divided into 3 groups according to ovarian stimulation protocols: the long GnRHa protocol group（186 cycles）, the short GnRHa protocol group （41 cycles） and the mini-stimulation protocol group（59 cycles）. The clinical characteristics and outcomes were compared among three groups. Results：In 164 patients, 112 patients（６８．３％） were aged ＜40, 21 cases （１２．８％） suffered from endometriosis and 5 cases （３％） pelvic tuberculosis, while 28 cases （１７．１％） had the pelvic operation history. The days and the amounts of Gn in the mini-stimulation protocol group were significantly less than those in other two groups （Ｐ＜０．０５）. The mean number of collected oocytes in the mini-stimulation protocol group was significantly lower than that in the long GnRHa protocol group, and the rate of frozen embryos was significantly higher（both P＜0.05）; but there were not significant differences between the mini-stimulation protocol group and the short GnRHa protocol group（both P＞0.05）. Conclusions：The mini-stimulation protocol is an preferable option for POR patients.

Key words: Ovary, Periodicity, Ovulation induction, Embryo transfer, Fertilization in vitro