Abstract: Preeclampsia（PE） is one of the main causes for the death of pregnant women. The developmental disorders of placental trophoblastic cells are related to the pathogenesis of PE. The malfunction of placenta may result in a high oxidative stress at the feto-maternal interface，which stimulates the excessive production of various factors from placenta. Those soluble placental factors are released into maternal circulation，eventually leading to the maternal symptoms of PE. Those hormones and molecules secreted by placenta, such as VEGF and anti-VEGF, methoxyestradiol, atrial natriuretic peptide, activin A and inhibin A, could partly reflect the developmental disorders of placenta. miRNAs and genetics were also found to be related to the pathogenesis of PE.

Key words: Pre-eclampsia, Placenta, Growth disorders, MicroRNAs