Abstract: Liver X receptors （LXRs）are members of the nuclear receptor superfamily. They can enhance the de novo lipogenesis through the activation of sterol response element binding protein-1c（SREBP-1c）. Moreover, LXRs have a close correlation with adipogenesis, since their activation may have participated in
the process of preadipocyte differentiation. This article reviews the molecular mechanism by which the LXRs act to influence lipogenesis and adipogenesis, thus to give a clue on researches of adipocyte differentiation in embryonic stem cell.

Key words: Liver X receptor, Lipogenesis, Adipogenesis, Differentiation