Abstract: B-cell specific moloney leukemia virus insertion site 1（BMI-1） gene, as an oncogene, is a regulating gene of polycomb group（PcG） gene family. BMI-1 plays an important role in proliferation of stem cell, cellular self-renew and ageing. In recent years, it was found that BMI-1 expressed abnormally in a wide variety of tumors, such as breast cancer, liver cancer and nasopharyngeal darcinoma, BMI-1 is closely related to the occurrence and development of tumor, so it can be used in diagnosis, assessment and prognosis of tumors. At present, study of BMI-1 in gynecologic oncologists was less, but it has been shown that BMI-1 was closely related to the development of gynecological cancer. We believed that BMI-1 would be a candidate factor for the diagnosis, treatment and prognosis of gynecological tumors.

Key words: BMI-1, Genital neoplasms, female, Oncogenes, Gene expression, Diagnosis