Abstract: Although assisted reproductive technology （ART） has been widely used in the infertile treatment now，there are potential effects on ART safety，such as the potential changes in epigenetics in ART offspring，especial those ART techniques including ICSI and IVF-ET. It is necessary to study further whether those potential epigenetic changes adversely affect offspings. H19 gene，as a maternal gene，is one of the imprinting genes which were firstly identified. Research showed that H19 gene variation was associated with the epigenetic changes of offspring. In this paper，the relationship between H19 gene and ART safety was reviewed.

Key words: Reproductive techniques, assisted, Infertility, female, Genomic imprinting, Gene expression regulation, H19 gene