Abstract: Long non-coding RNAs (lncRNAs) are a kind of functional RNA molecules with longer than 200 nucleotides. Although lncRNAs have not the protein-coding function, they are involved in epigenetic control, and transcriptional/post-transcriptional modification, suggesting that lncRNAs are key regulators in many pathological and physiological processes. There are thousands of lncRNAs in human and animals, including some reported lncRNAs which are related to gynecological diseases such as cervical cancer, endometriosis, PCOS, endometrial cancer, ovarian cancer and so on. With the development of lncRNA research, lncRNAs will play an important role in the tertiary prevention (early detection, early diagnosis, early treatment) . However, the mechanism of lncRNAs and the relationship with diseases are still unclear. In this review, the research progress on lncRNAs′ function, the pathological and pathophysiological roles in gynecological diseases, and the potential application of lncRNAs in the diagnosis and therapy of gynecological diseases were summarized.

Key words: Long non-coding RNA, Epigenesis, genetic, Endometriosis, Genital diseases, female