Abstract: Objective: To investigate the perinatal outcomes of offsprings from IVF/ICSI. Methods: The clinical data and perinatal outcomes of 840 cycles of fresh embryo transfer or frozen-thawed embryo transfer（FET） were retrospectively analyzed in our hospital from January 2012 to December 2013. Results: The birth weight [（2 536.84±417.23）g vs.（3 314.67±466.56）g] and the gestational age[（３６．７８±１．７４）week vs.（３９．３１±１．４５）week] of the twins were significantly lower than singletons（Ｐ＜０．０５）. The rates of premature birth（45.66% vs. 3.70%）, low birth weight（41.32% vs. 2.41%） and cesarean section（97.26% vs. 81.64%） in the twins were significantly higher than the singletons（Ｐ＜０．０５）. The birth weight[（3 358.96±458.34）g vs. （3 249.11±474.28）g] and the cesarean section （85.97% vs. 74.58%）in the singletons of FET group were significantly higher than those in the fresh embryo transfer group （P＜0.05）. Conclusions: The twins of ART have more adverse perinatal outcomes than the singletons. The singletons of FET have better outcomes than the singletons of fresh embryo transfer.

Key words: Reproductive techniques, assisted, Twins, Pregnancy outcome, Premature birth, Infant, low birth weight, Sex ratio