国际生殖健康/计划生育杂志 ›› 2023, Vol. 42 ›› Issue (1): 54-59.doi: 10.12280/gjszjk.20220477

• 综述 • 上一篇    下一篇

慢性牙周炎对人类生殖健康的不利影响

周创, 张宸极, 陈宣凝, 冯逸升, 丁之德()   

  1. 200025 上海交通大学医学院2020级口腔医学系(周创,张宸极,陈宣凝,冯逸升),组织胚胎学与遗传发育学系(丁之德)
  • 收稿日期:2022-10-10 出版日期:2023-01-15 发布日期:2023-02-03
  • 通讯作者: 丁之德 E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学医学院“第十六期RBL项目”

The Detrimental Effects of Chronic Periodontitis on Human Reproductive Health

ZHOU Chuang, ZHANG Chen-ji, CHEN Xuan-ning, FENG Yi-sheng, DING Zhi-de()   

  1. Department of Stomatology, Grade 2020 (ZHOU Chuang, ZHANG Chen-ji, CHEN Xuan-ning, FENG Yi-sheng), Department of Histology, Embryology, Genetics and Developmental Biology (DING Zhi-de), Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2022-10-10 Published:2023-01-15 Online:2023-02-03
  • Contact: DING Zhi-de E-mail:zding@shsmu.edu.cn

摘要:

慢性牙周炎是一种由微生物菌斑引发的、累及牙周组织结构的牙周疾病。近年研究表明,牙周炎与多种全身性疾病包括生殖系统疾病有关。牙周炎可参与女性生殖系统疾病发生发展,如不孕症、多囊卵巢综合征、子宫内膜异位症等;而对于男性患者,牙周炎可能与勃起功能障碍、不育症、前列腺疾病等也相关。因此,牙周炎不仅会对生育力造成负面影响,与此相关的子宫内膜异位症及其恶性病变、前列腺癌等还会给患者带来沉重的生存压力和经济负担。综述牙周炎与人类生殖可能的相关关系,对提升育龄人群的生殖健康具有一定的意义。

关键词: 慢性牙周炎, 不育,女(雌)性, 不育,男(雄)性, 多囊卵巢综合征, 子宫内膜异位症, 勃起功能障碍, 前列腺疾病

Abstract:

Chronic periodontitis is a kind of periodontal disease caused by microbial plaque that involves periodontal tissues. Recently, several studies have shown an association between periodontitis and various systemic diseases in humans, including reproductive diseases. For example, periodontitis may induce female reproductive diseases such as infertility, polycystic ovary syndrome, endometriosis, etc. For males, periodontitis is closely correlated to erectile dysfunction, infertility and prostate diseases. Therefore, periodontitis may have detrimental effects on the human fertility. The periodontitis-related endometriosis and followed malignant lesions, as well as prostate cancer, may also bring a entail underestimated survival pressure on the patients and a heavy economic burden on the society. In this paper, we discuss the detrimental effects of periodontitis on human reproduction, and the potential improving effects of the prevention and treatment of chronic periodontitis on the reproductive health of childbearing-age population.

Key words: Chronic periodontitis, Infertility, female, Infertility, male, Polycystic ovarian syndrome, Endometriosis, Erectile dysfunction, Prostatic diseases