国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 8-10.

• 论著 • 上一篇    下一篇

多囊卵巢综合征糖耐量与谷氨酸脱羧酶抗体测定分析

罗海宁;张印峰; 徐凤琴; 高企贤   

  1. 天津中心妇产科医院生殖助孕中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15

Analysis of GAD Antibody in 73 Patients with PCOS

LUO Hai-ning;ZHANG Yin-feng;XU Feng-qin;GAO Qi-xian   

  1. ART Center，Tianjin Obstetric and Gynecology Central Hospital，Tianjin 300052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15

PDF (PC)

7232

摘要： 目的：探讨多囊卵巢综合征(PCOS)患者糖耐量与谷氨酸脱羧酶抗体(GADA)的关系。方法：选择PCOS患者73例，其中糖耐量正常（A组）35例；糖耐量异常（B组）38例。比较两组患者年龄、内分泌及糖耐量和胰岛素释放实验和GADA指标是否存在差异。依据GADA检测结果再将73例分组，27例GADA阳性（C组），46例阴性（D组），比较两组患者年龄、内分泌及糖耐量和胰岛素释放实验是否存在差异。结果： GADA阳性27例，阳性率为36.9%。B组患者的体质量指数明显高于A组；B组患者空腹血糖(FPG)和餐后2h血糖以及餐后2h的胰岛素水平明显高于A组，有统计学差异。B组空腹胰岛素水平、GADA水平均高于A组，但无统计学意义。A，B组患者年龄、不孕时间、基础内分泌检测无统计学意义。C，D组患者年龄、不孕时间、体质量指数及糖耐量和胰岛素释放试验无统计学意义。结论：尽管GADA是一种检测成人隐匿性自身免疫性糖尿病(LADA)的有效指标，但PCOS患者糖代谢与GADA的关系依需进一步研究。

关键词: 多囊卵巢综合征, 成人隐匿性自身免疫性糖尿病, 谷氨酸脱羧酶抗体

Abstract: Objective: to investigate the relationship between glucose metabolism and GADA in PCOS patients. Methods: Seventy-three PCOS patients who attended to our center from 2009-5 to 2009-10 are divided into 2 groups: group A has 35 patients whose glucose tolerance test are normal while group B has 38 patients whose glucose tolerance test are abnormal. The same 73 patients are divided again according to the GADA test: group C has 27 patients who are GADA positive while group D has 46 patients who are GADA negative. The differences of age, BMI, endocrine test, glucose and insulin releasing test and GADA results between group A, B and group C, D were compared. Results: Twenty-seven patients are the GADA positive and the positive rate is 36.9%. The BMI, FPG, 2h glucose and insulin releasing test in group B are higher than those in group A. Fasting insulin and GADA test in group B are higher than those in group A which showed no statistical differences. There are no differences of age, infertile time and endocrine test between group A, B and group C, D. Conclusion: Further research is needed to illustrate the relationship between PCOS and LADA even though the GADA is an effective index to diagnose the LADA.

Key words: PCOS, LADA, GADA