国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (3): 239-242.

• 综述 • 上一篇    下一篇

氧化应激对辅助生殖技术的影响

欧蕾;郭艺红;孙莹璞   

  1. 450052 郑州大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-05-15 发布日期:2010-05-15

The Effect of Oxidative Stress on Assisted Reproductive Techniques Setting

OU Lei,GUO Yi-hong,SUN Ying-pu   

  1. The Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-05-15 Online:2010-05-15

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摘要： 氧化应激的发生源于反应性氧化物与生物抗氧化剂之间的平衡破坏，造成活性氧浓度升高，导致细胞氧化损伤。人类许多不同生殖状态下都存在氧化应激状态，尤其是辅助生殖技术（ART）过
程中，体外操作不能模拟真实的体内生理条件，多种因素都可能导致氧化应激的产生及增加，其作用于精子、卵子、子宫内膜及胚胎等，影响胚胎着床，从而影响ART治疗结局，就ART 过程中出现氧化应激状态的可能性及目前有效预防措施综述。

关键词: 氧化应激, 辅助生殖技术, 不孕症, 精子, 卵母细胞

Abstract: The manipulation of gametes and embryos in an in vitro environment when performing assisted reproductive techniques（ART）carries the risk of exposure of these cells to supraphysiological levels of reactive oxygen species（ROS）. The main objective of this review articles is to provide ART personnel with
all the necessary information regarding the development of oxidative stress in an ART setting，as well as the sources of ROS and the mechanisms of oxidative stress-induced damage during ART procedures. The impact of oxidative stress on ART outcomes and the different strategies designed to prevent it are also discussed.

Key words: Oxidative stress, Assisted reproductive techniques, Infertilitas feminis, Sperm, Oocyte