国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (6): 436-437.

• 论著 • 上一篇    下一篇

母血、脐血内脂素与新生儿体质量相关性研究

林小满,孙礼强,林新生   

  1. 430064 武汉科技大学附属天佑医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 林小满

The Relationship Between Visfatin Levels in Maternal and Neonatal Serum and Newborn Birth Weight

LIN Xiao-man, SUN Li-qiang, LIN Xin-sheng   

  1. Department of Gynaecology and Obstetrics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-11-15 Online:2011-11-15
  • Contact: LIN Xiao-man

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摘要： 目的：探讨母体外周血和脐血中血清内脂素（visfatin）水平与新生儿出生体质量的关系。方法：根据新生儿出生体质量，将妊娠妇女分为足月分娩小于胎龄儿组（SAG组）、适于胎龄儿组（AGA组）、大于胎龄儿组（LGA组），各组产妇择期剖宫产术当日清晨抽取空腹肘正中静脉血并分离血清，用酶联免疫吸附测定（ELISA）检测血清内脂素水平，记录新生儿出生体质量，用SPSS 17.0进行统计学分析。结果：3组母体外周血内脂素浓度呈增高趋势，组间差异有统计学意义（F=500.04，P＜0.05）；3组脐血内脂素浓度呈增高趋势，组间差异有统计学意义（F=354.69，P＜0.05）；母体外周血和脐血内脂素浓度与新生儿出生体质量呈正相关（r分别为0.528和0.609，均P＜0.05）。结论：内脂素作为新的脂肪因子，参与了胎儿宫内生长发育，可作为预测胎儿体质量的指标。

关键词: 妊娠, 烟酰胺磷酸核糖基转移酶, 出生体重, 酶联免疫吸附测定

Abstract: Objective: To investigate the relationship between visfatin levels in maternal serum and umbilical core serum and birth weight. Methods: According to newborn birth weight, sixty cases of pregnancy ｗｏｍｅｎ ｉｎ ｌａｔｅ ｔｒｉｍｅｓｔｅｒ ｗｅｒｅ ｄｉｖｉｄｅｄ ｔｏ ｔｈｒｅｅ ｇｒｏｕｐｓ： ｓｍａｌｌ ｆｏｒ ｇｅｓｔａｔｉｏｎａｌ ａｇｅ（ＳＧＡ）， ａｐｐｒｏｐｒｉａｔｅ ｆｏｒ ｇｅｓｔａｔｉｏｎａｌ ａｇｅ（ＡＧＡ）， ｌａｒｇｅ ｆｏｒ ｇｅｓｔａｔｉｏｎａｌ ａｇｅ（ＬＧＡ）． Ｆａｓｔ?鄄ｂｌｏod samples were collected on the day of elective caesarean section, sera visfatin was analysed by ELISA. Newborn birth weight was recorded. Statistical analysis was made by SPSS17.0. Results: The visfatin concentrations in maternal serum of SGA， AGA and LGA group were statistically significant（Ｆ＝５００．０４， Ｐ＜０．０５）； similar increase of visfatin level was found in umbilical core serum of SGA, AGA and LGA group（Ｆ＝３５４．６９， Ｐ＜０．０５）． The positive correlation was found between newborn birth weight and the visfatin concentration in maternal serum or umbilical core（ｒ＝０．５２８ ａｎｄ ｒ＝０．６０９， ｒｅｓｐｅｃｔｉｖｅｌｙ， Ｐ＜０．０５）. Conclusions: Visfatin, a new fat factor, participates in the regulation of fetal growth in uterus. It can be used as a marker of fetal weight.

Key words: Pregnancy, Nicotinamide phosphoribosyltransferase, Birth weight, Enzyme?鄄linked immunosorbent assay