国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 108-114.

• 综述 • 上一篇    下一篇

人类辅助生殖技术的临床研究和进展

张寅,伍琼芳   

  1. 330006南昌，南昌大学研究生院医学部（张寅）；江西省妇幼保健院辅助生殖中心（伍琼芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 伍琼芳

The Clinical Research and Development of Human Assisted Reproductive Technology

ZHANG Yin，WU Qiong-fang   

  1. Medical College of Nanchang University, Nanchang 330006, China（ZHANG Yin)；Reproductive Medicine Center, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China（WU Qiong-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: WU Qiong-fang

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摘要：

不孕不育是一个高度遍及全球的生殖健康问题，近年来不孕症患者呈逐年增长趋势。该
病已成为影响人类发展与健康的一个全球性医学和社会学问题。自从1978年世界上首例“试管婴儿”—

英国的Louise Brown经体外受精（IVF）而诞生，辅助生殖技术（ART）逐渐成为不孕夫妇的重要治疗手段。
ART包括人工授精（AI）、体外受精与胚胎移植（IVF-ET）、胞浆内单精子注射（ICSI）、生殖细胞及胚胎冷冻
技术等。而其他ART也在快速改革发展，包括一些建立在辅助生殖与人类基因组之间的桥梁。一系列辅助
生殖相关技术，如未成熟卵母细胞体外培养成熟（IVM）、移植前遗传学诊断（PGD）、单胚胎移植以及冷冻
技术等获得了较大的发展，为降低常规IVF-ET的费用、风险等提供了可能。综述当前临床及实验性ART技
术的相关研究进展

关键词: 生殖技术, 辅助, 受精, 体外, 胚胎移植, 精子注射, 细胞质内, 植入前诊断, 胚胎培养技术, 低温保存

Abstract: Infertility is a global reproductive health problem，the number of patients with infertility has
increased year by year. Since the first "test-tube baby" in the world, UK's Louise Brown, was born via in vitro
fertilization（IVF）in 1978，assisted reproductive technology（ART）has been the leading surgical treatment for
couples diagnosed with infertility. ART included artificial insemination（AI）、in vitro fertilization and embryo
transfer（IVF-ET）、intracytoplasmic sperm injection（ICSI）、embryo cryopreservation technology and so on.
Many other ARTs are been rapidly evoluting，such as some ARTs based on human genomics. A series of new
ARTs, such as in vitro oocyte maturation (IVM), preimplantation genetic diagnos（PGD）, single embryo transfer,
gamete and embyo freezing and frost thawing technology, have been developed. These new ARTs provided
possibilities to reduce cost and risk of routine in vitro fertilization and embryo transfer（IVF-ET）. In this paper,
we reviewed the clinical and experimental progress of ARTs

Key words: Reproductive techniques, assisted, Fertilization in vitro, Embryo transfer, Sperm injections, intracytoplasmic, Preimplantation diagnosis, Embryo culture techniques, Cryopreservation