国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 123-125.

• 综述 • 上一篇    下一篇

内质网应激的发生及其与多囊卵巢综合征的关系

王影,魏兆莲   

  1. 230022合肥，安徽医科大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 魏兆莲

Endoplasmic Reticulum Stress and Polycystic Ovary Syndrome

WANG Ying，WEI Zhao-lian   

  1. Reproductive Center of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: WEI Zhao-lian

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摘要： 内质网（endoplasmic reticulum，ER）是最大的细胞器之一，是细胞膜所有组件、蛋白、脂类
和类固醇合成的部位。当未折叠/错误折叠蛋白在内质网内堆积时将导致内质网应激（endoplasmic
reticulum stress，ERS）。ERS是ER生理功能发生紊乱的一种病理状态，是机体的一种自我防御机制，持久
而强烈的ERS可引起细胞不可逆损伤甚至凋亡，因此其是促细胞凋亡的一条重要途径。多囊卵巢综合征患
者卵巢窦卵泡颗粒细胞异常凋亡，表明ERS介导的颗粒细胞凋亡可能与多囊卵巢综合征的发生有关。

关键词: 多囊卵巢综合征, 内质网, 应激, 粒层细胞, 细胞凋亡

Abstract: The endoplasmic reticulum (ER), one of the largest cellular organelles, serves as many
essential functions，including production of all components of cellular membranes, proteins, lipids, and steroids.
When unfold/mis-fold proteins were over -accumulated in ER, Endoplasmic reticulum stress (ERS) will be
induced. ERS, a self -defence mechanism, is a pathological condition of the functional disorder of ER. The
strong and long -lasting ERS could lead the irreversible cell injury, even apoptosis. The granulosa cells
abnormally apoptosis follicles of PCOS ovaries, which suggested that granulosa cells apoptosis by ERS may be
involved in PCOS pathogenesis.

Key words: Polycystic ovary syndrome, Endoplasmic reticulum, Stress, Granulosa cells, Apoptosis