国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 442-444.

• 论著 • 上一篇    下一篇

孕激素受体和孕激素诱导的封闭因子的表达与自然流产的关系


陈志芳, 谭 丽   

  1. 461200 河南省许昌市鄢陵县人民医院（陈志芳）；郑州大学第二附属医院生殖中心（谭 丽）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 谭丽

The Expression of Progesterone Receptor and Progesterone Induced Blocking Factor and Association to Spontaneous Abortion

CHEN Zhi-fang，TAN Li   

  1. The People′s Hospital of Yanling County，Xuchang 461200，He′nan Province，China（CHEN Zhi-fang）；The Reproductive Center of the Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450014，China（TAN Li）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15
  • Contact: TAN Li

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摘要： 目的：探讨孕激素受体（PR）和孕激素诱导的封闭因子（PIBF）在妊娠早期自然流产发病机制中的作用。方法：选取妊娠早期自然流产患者25例做病例组，同期妊娠早期正常妊娠要求行人工流产者20例为对照组，采用免疫组织化学SP法检测2组蜕膜组织中PR和PIBF的表达水平。结果：2组蜕膜组织中均可检测到PR和PIBF的表达。病例组和对照组蜕膜组织中PR表达的阳性率分别为80%（20/25）和85%（17/20），PIBF表达的阳性率分别为76%（19/25）和75%（15/20），2组间差异均无统计学意义（χ2=0.002，P＝0.975；χ2=0.006，P＝0.950），但对照组PR和PIBF的表达强度均高于病例组，差异有统计学意义（Zc=2.261，P＝0.020；Zc=2.463，P＝0.010）。病例组和对照组蜕膜组织中PR与PIBF表达均呈正相关（rs分别为0.759和0.706，均P=0.000）。结论：子宫蜕膜组织中PR和PIBF表达的降低与自然流产的发生有关，是母体复杂网络中的一个微小侧面。

关键词: 流产, 自然, 蜕膜, 受体, 孕酮, 孕激素诱导的封闭因子

Abstract: Objective：To compare the expressions of progesterone receptor （PR） and progesterone induced blocking factor （PIBF） in the decidua tissues of early normal pregnancy and spontaneous abortion in early gestation stage. Methods：Twenty-five cases of early spontaneous abortion women （as the study group） and 20 cases of healthy women with early normal pregnancy （as the control group） were recruited. The expressions of PR and PIBF in the decidua tissues were detected by the streptavidin peroxidase immunostaining. Results：PR and PIBF expressed in the decidua tissues of both groups. There was no significant difference in the expression positive rates of PR and PIBF between two groups （χ2=0.002，P＝0.975； χ2=0.006，P＝0.950），but the expression intensity of PR and PIBF in the control group were stronger than those of the study group（Zc=2.261，P＝0.020；Zc=2.463，P＝0.010）. Conclusions：The lower expressions of PR and PIBF in the decidua tissue could be associated with early spontaneous abortiｏｎ，ｗhich reflected a pathway of the maternal complicated network related to early spontaneous abortion.

Key words: Abortion, spontaneous, Decidua, Receptors, progesterone, Progesterone-induced blocking factor