国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (4): 281-283.

• 论著 • 上一篇    下一篇

邻苯二甲酸酯类化合物暴露情况与自然流产的关系

高福梅, 蔡晓辉, 沈 浣   

  1. 100044 北京大学人民医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 沈 浣

Exposure of Phthalic Acid Esters and Spontaneous Abortion

GAO Fu-mei,CAI Xiao-hui,SHEN Huan   

  1. Reproductive Center in Peking University Peoples′ Hospital,Beijing 100044,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-07-15 Online:2013-07-15
  • Contact: SHEN Huan

摘要: 目的:研究邻苯二甲酸酯类化合物(PAEs)暴露与自然流产的关系。方法:选取2009年6月—2012年12月的107例胚胎停育患者与152例早孕人工流产患者进行流行病学问卷调查,利用病例-对照研究的方法,从PAEs暴露角度探讨PAEs与自然流产发病的关系。结果:Logistic逐步回归统计分析发现家庭装修时间越短(OR=0.88,95%CI:0.81~0.96,P=0.00)、办公室夏天通风时间越短(OR=0.95,95%CI:0.90~1.00,P=0.04)、保鲜膜使用越多(OR=1.14,95%CI:1.00~1.29,P=0.047)自然流产的相对危险越增加,而房屋清扫次数越多(OR=3.50,95%CI:1.60~7.64,P=0.00)发生自然流产的相对危险性越小。结论:目前PAEs的环境污染可能是导致自然流产的原因之一。

关键词: 二乙基己基邻苯二甲酸, 流产, 自然, 环境暴露, 问卷调查, 邻苯二甲酸酯类化合物

Abstract: Objective: To investigate the relationship between phthalic acid esters (PAEs) exposure and sponstaneous abortion. Methods:In this retrospective study,107 spontaneous abortion cases and 152 induced abortion cases of early pregnancy were included,from January 2009 to December 2012. All the patients enrolled were required to complete a survey questionnaire about PAEs exposure. Results:By statistical analysis of logistic regression,it was showed that the shorter after the house decoration (OR=0.88,95%CI:0.81-0.96,P=0.00),the less office ventilation in summer (OR=0.95,95%CI:0.90-1.00,P=0.04) and the more utilization of preservative film(OR=1.14,95%CI:1.00-1.29,P=0.047),the higher relative risk of spontaneous abortion. In contrast,it was also observed that the more frequent of housecleaning (OR=3.50,95%CI:1.60-7.64,P=0.00),the lower relative risk of spontaneous abortion. Conclusions:The environmental pollutant of PAEs may be one of risk-factors of spontaneous abortion.

Key words: Diethylhexyl phthalate, Abortion, spontaneous, Environmental exposure, Questionnaires, Phthalic acid esters