国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 391-394.

• 综述 • 上一篇    下一篇

卵巢过度刺激综合征的研究现状

姜李乐, 曹国昌, 梁琳琳, 张翠莲   

  1. 450003 郑州大学人民医院生殖医学研究所（姜李乐，梁琳琳，张翠莲）；河南科技大学药理学与医学分子生物学实验室（曹国昌）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15

Progress in Ovarian Hyperstimulation Syndrome

JIANG Li-le，CAO Guo-chang，LIANG Lin-lin，ZHANG Cui-lian   

  1. Medical Reproduction center of Henan Province People's Hospital，Zhengzhou 450003，China（JIANG Li-le，LIANG Lin-lin，ZHANG Cui-lian）；The Laboratory of Pharmacology and Medical Molecular Biology，College of Medicine，Henan University of Science and Technology，Luoyang 471003，China（CAO Guo-chang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

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摘要： 卵巢过度刺激综合征（OHSS）是一种外源性或内源性促性腺激素所致的综合征。主要与使用外源性促性腺激素有关，偶见于使用氯米芬促排卵者，自然周期妊娠者较罕见。近年来，随着无排卵型不孕症发病率的逐年增高，在体外受精-胚胎移植（IVF-ET）中，控制性超促排卵是必要步骤。OHSS渐渐成为辅助生殖技术（ART）最常见最具潜在危险的并发症。其不但影响胚胎着床发育，严重者还会危及患者生命。综述近几年来OHSS发病机制、临床表现、预防及治疗等方面的研究现状。

关键词: 卵巢过度刺激综合征, 促性腺素类, 排卵诱导, 受精, 体外, 胚胎移植, 生殖技术, 辅助

Abstract: Ovarian hyperstimulation syndrome（OHSS） is an exogenous or endogenous gonadotropin-induced syndrome. OHSS is associated mainly with exogenous gonadotropin，occasionally with Clomiphene，rarely with the natural cycles of pregnancy. In recent years，with the increasing incidence of anovulatory infertility，the controlled ovarian hyperstimulation becomes a necessary step in in vitro fertilization and embryo transfer. OHSS gradually became one of the most common complications with potentially high-dangerous in assisted reproductive technology. OHSS affects embryo implantation and embryo development, and it could be fatal in some severe cases. The research progress on the pathogenesis，clinical manifestations，prevention and treatment of OHSS were discussed in this review.

Key words: Ovarian hyperstimulation syndrome, Gonadotropins, Ovulation induction, Fertilization in vitro, Embryo transfer, Reproductive techniques, assisted