国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 485-489.

• 综述 • 上一篇    下一篇

人绒毛膜促性腺激素在辅助生殖技术中的应用


聂晓倩,于新艳   

  1. 271000 山东省泰安市中心医院生殖遗传科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15

Application of hCG in Assisted Reproductive Technology

NIE Xiao-qian, YU Xin-yan   

  1. Department of Reproduction and Genetics,Tai An Central Hospital，Tai′an 271000, Shandong Province, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15

PDF (PC)

7332

摘要： 人绒毛膜促性腺激素（hCG）是胎盘合体滋养细胞合成的一种糖蛋白激素，是妊娠信号分子。hCG与黄体生成激素（LH）结构相似，且拥有共同的受体。但前者与受体的结合力更强，具有更长的半衰期。因此，外源性hCG常用于体外受精-胚胎移植中促进卵泡成熟及黄体支持、维持妊娠。随着研究的深入，人们发现hCG除上述作用外，还有利于卵泡的募集、生长发育及胚胎种植。总之，hCG在辅助生殖领域的作用十分重要。

关键词: 绒毛膜促性腺激素, 生殖技术, 辅助, 卵泡, 胚胎植入

Abstract: hCG, a glycoprotein hormone produced by placental syncytiotrophoblast, is a signal molecules of pregnancy. Though hCG has similar structure and same receptor with LH, hCG has higher binding affinity with receptor and longer half-life period when compared with LH. So, exogenous hCG is often used to promote follicular maturation and to support the luteal phase. Besides those effects, hCG is beneficial to follicular raise, growth and development, and to embryonic implantation. In a word, hCG plays an important role in ART clinic and basic research.

Key words: Chorionic gonadotropin, Reproductive techniques, assisted, Ovarian follicle, Embryo implantation