国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (4): 325-328.

• 综述 • 上一篇    

肥胖在流产中的作用研究新进展

袁海琳，吴庆丽   

  1. 518110 深圳市宝安区福永人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-07-15 发布日期:2014-07-15
  • 通讯作者: 袁海琳

Obesity and Spontaneous Abortion

YUAN Hai-lin，WU Qing-l

  

  1. Bao′an District Fuyong People′s Hospital，Shenzhen 518110，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-07-15 Online:2014-07-15
  • Contact: YUAN Hai-lin

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摘要： 妊娠妇女肥胖与流产之间的关系日益受到关注。对于因不孕接受治疗的女性，肥胖者发生流产的机会增加。肥胖女性应在体质量得到有效控制后再考虑妊娠；对于自然妊娠的女性，肥胖亦会增加流产风险。多数研究表明，肥胖导致的内分泌功能紊乱是引发流产的主要机制，肥胖患者多数存在高胰岛素血症及胰岛素抵抗（IR），其中Ⅰ型纤溶酶原激活剂抑制物（PAI-1）、雄激素、胰岛素样生长因子等分别在发病机制中起不同作用。另外，子宫内膜容受性降低、子宫内膜血流减少、染色体核型异常等也是肥胖导致流产的原因。综述肥胖在流产中的作用机制。

关键词: 肥胖症, 流产, 人体质量指数, 胰岛素抗药性

Abstract: Gestational obesity and correlative abortion are becoming the focus. In those infertile women, obese women have higher risk of abortion. So, obese women are suggested to control well their weight before pregnancy. In those women with natural pregnancy, obese women have also increased risk of abortion. Most studies showed that the endocrine disorders related with obesity were the main mechanism of abortion. Most obese patients are accompanied with hyperinsulinism and insulin resistance, while the plasminogen activator inhibitor-1 （PAI-1）, androgen and insulin-like growth factor play different roles in the pathophysiology. In addition, the decreased uterine receptivity, the reduced endometrial blood flow and abnormal karyotype are reasons of abortion in obese women. In this paper, the mechanism of abortion in obese women was reviewed.

Key words: Obesity, Abortion, Body mass index, Insulin resistance