国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (5): 396-400.

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哺乳动物胚胎植入分子机制的研究进展

张省，叶彬，丁之德   

  1. 200025 上海交通大学医学院临床医学系（张省，叶彬），解剖学与组织胚胎学系（丁之德）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-15 发布日期:2014-09-15

Molecular Mechanisms of Mammalian Embryonic Implantation

ZHANG Xing，YE Bin，DING Zhi-de   

  1. Department of Clinical Medicine，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China（ZHANG Xing，YE Bin）；Department of Human Anatomy，Histology and Embryology，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China（DING Zhi-de）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-15 Online:2014-09-15

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摘要： 哺乳动物胚胎植入是胚胎滋养层与子宫内膜相互融合的过程。成功植入需要:①子宫内膜具有容受性；②正常和功能完善的且处于胚泡发育期的胚胎；③母体与胚胎组织发育同步且功能协调。胚胎植入子宫内膜需要经过定位、黏附、穿透三个过程。近年来，不断有新的研究发现在胚胎植入中有许多重要的基因和蛋白分子及相关的作用机制参与该过程，如硫酸软骨素蛋白聚糖4（CSPG4）、表皮生长因子（EGF）、血管内皮生长因子（VEGF）和微小RNA（ｍｉＲＮＡ）等。明确这些关键基因和蛋白分子在胚胎植入时作用的分子机制，有助于未来临床不孕症的诊断、治疗及预防。

关键词: 哺乳动物, 胚胎植入, 子宫内膜, 分子机制

Abstract: Embryonic implantation in mammalian is the process of fusion between embryo trophoblast and endometrium. A successful implantation requires：endometrium receptivity；a normal and functional embryo at the blastocyst developmental stage；synchronized development and functional coordination of maternal and embryonic tissues. The implantation process is composed of apposition，adhesion and invasion. Recently，new studies revealed that a lot of crucial genes，protein molecules and their related signaling pathways participated in the mammalian embryo implantation，such as CSPG4，EGF，VEGF，and etc. It is beneficial to the diagnosis，treatment and prevention of infertility in future to elucidate those critical genes，molecules and related mechanisms in the process of embryonic implantation.

Key words: Mammals, Embryo implantation, Endometrium, Molecular mechanism