国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (4): 315-318.

• 综述 • 上一篇    下一篇

let-7c对卵巢功能的调控作用

洪黎明，杨晓葵   

  1. 100026 北京，首都医科大学附属北京妇产医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 杨晓葵

Roles of let-7c in Regulating Ovarian Function

HONG Li-ming，YANG Xiao-kui   

  1. Department of Reproductive Medicine，Beijing Obstetrics and Gynecology Hospital，Capital Medical University，Beijing 100026，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-07-15 Online:2015-07-15
  • Contact: YANG Xiao-kui

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摘要： 正常的卵巢功能不仅受下丘脑-垂体-卵巢轴神经内分泌活动的调控，还与卵巢自分泌与旁分泌有关。内分泌激素、细胞因子、生长因子等多种因素的协调作用共同维持正常的卵巢周期，任何因素调节异常都会导致卵巢功能障碍或卵巢疾病的发生。微小RNA（microRNA，miRNA）是一类能在转录后水平对基因表达进行负调控的非编码单链小RNA，参与机体多种生理与病理过程。let-7c是目前研究最为广泛的miRNA之一，近年研究表明let-7c除了与肿瘤的发生、发展密切相关，还通过多种信号转导途径参与卵巢颗粒细胞增殖、分化和凋亡过程，在卵泡发育、卵巢激素的合成与作用、卵巢早衰及卵巢癌的发病过程中也具有重要作用。

关键词: 微RNAs, 卵泡, 卵巢功能早衰, 卵巢肿瘤, let-7c

Abstract: Normal ovarian functions are not only controlled by the hypothalamic-pituitary-ovarian axis, but also regulated by autocine and paracrine systerms in the ovary. The coordinating roles among endocrine hormones, cytokines, growth factors and many other factors are essential for normal ovarian functions. Any dysregulation of these factors may result in ovarian dysfunction and ovarian diseases. MicroRNAs（miRNAs） are a class of non-coding single-stranded RNA molecules, which negatively regulated gene expression at post-transcriptional level and involved in a variety of physiological and pathological processes. Let-7c is one of the most widely studied miRNAs at present. Recent studies suggested that let-7c was related to the occurrence and development of tumor. In addition, let-7c regulates proliferation, differentiation and apoptosis of ovarian granulosa cells through various signal pathways, showing its important roles in follicular development, ovarian hormone synthesis and function, premature ovarian failure and ovarian cancer.

Key words: MicroRNAs, Ovarian follicle, Ovarian failure, premature, Ovarian neoplasms, let-7c