国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (2): 155-159.

• 综述 • 上一篇    下一篇

丝裂原活化蛋白激酶磷酸酶-1在妇产科相关疾病中的研究进展

苏琳，陈琼华   

  1. 361004 福建省厦门市，厦门大学附属第一医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 陈琼华

Research Progress of Mitogen-activated Kinase Phosphatase-1 in Obstetrical and Gynecological Related Diseases

SU Lin，CHEN Qiong-hua   

  1. Department of Obstetrics and Gynecology，The Affiliated First Hospital of Xiamen University，Xiamen 361004，Fujian Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-03-15 Online:2016-03-15
  • Contact: CHEN Qiong-hua

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摘要： 丝裂原活化蛋白激酶磷酸酶（mitogen-activated kinase phosphatase，MKPs）是一类在细胞内水解丝裂原活化蛋白激酶（mitogen-activated protein kinases，MAPKs）的家族，通过负向调控MAPKs参与细胞的应激、分化、增殖、凋亡等细胞过程，其异常表达与肿瘤的发生、发展密切相关。MKP-1是MKPs家族中被报道最多的成员，具有最强的去磷酸化能力。综述MKP-1在妇产科相关疾病，包括生殖器肿瘤、子宫内膜异位症以及子痫前期的研究进展，阐述MKP-1在疾病中的表达特征、病理作用及其机制；重点讨论了MKP-1在子宫内膜异位症发生发展中的作用，阐述了MKP-1与MAPKs的相互作用对子宫内膜异位症发生、发展过程的影响，为今后的研究方向提供参考。

关键词: 丝裂原激活蛋白激酶类, 双特异性磷酸酶1, 生殖器肿瘤, 女（雌）性, 子宫内膜异位症, 先兆子痫

Abstract: The mitogen-activated kinase phosphatase (MKPs), a intracellular phosphatase family that could hydrolyze the mitogen-activated protein kinases (MAPKs) in cells, participate in the regulation of cell stress, differentiation, proliferation and apoptosis by the negative feedback regulation of MAPKs. The abnormal expression of MKP-1 was associated with the cancer occurrence and development. MKP-1 shows the strongest ability of dephosphorylation, which has been well studied as a member of the MKPs family. In this review, we summarized the effects of MKP-1 in the diseases associated with obstetrics and gynecology, including genital neoplasms, endometriosis and preeclampsia. The expression pattern, pathological function and molecular mechanism of MKP-1 in obstetrical and gynecological diseases were elucidated. After that, we focused on the pathophysiological effect of MKP-1 in endometriosis. The interaction between MKP-1 and MAPKs could provide us more references for the prospective research.

Key words: Mitogen-activated protein kinases, Dual specificity phosphatase 1, Genital neoplasms, female, Endometriosis, Pre-eclampsia